| 项目编号: | NE/H013148/1
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| 项目名称: | Manufactured nanoparticle bioavailability and environmental exposure (nanoBEE) |
| 作者: | Jamie Lead
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| 承担单位: | University of Birmingham
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| 批准年: | 2009
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| 开始日期: | 2010-01-10
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| 结束日期: | 2015-31-08
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| 资助金额: | GBP704484
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| 资助来源: | UK-NERC
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| 项目类别: | Research Grant
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| 国家: | UK
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| 语种: | 英语
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| 特色学科分类: | Pollution, waste & resources 
; (80%)
; Terrest. & freshwater environ. 
; (20%)
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| 英文摘要: | The nano-BEE consortia will develop and refine, using empirical data, a critical subset of models focused on exposure to nanomaterials (NMs) and their bioavailability in the environment. The objectives of this study are to (a) generate controlled and well-characterized NMs libraries for environmental assessment (b) prove that soft landed gold clusters provide suitable fiducial markers to enable angstrom resolution in aquatic tomography of NMs in environmental media (c) demonstrate that NM environmental modification processes can be classified by the extent of aggregation, dissolution and surface modification and to experimentally and computationally describe the partition of these modified NMs between environmental compartments (d) to develop modified biodynamic models for NM bioavailability that reflect both water and food exposures and (e) to validate biotic ligand models for NM effects on aquatic organisms. An integrated computational and experimental program will examine the environmental chemistry of manufactured NMs using electron microscopy, scattering techniques, and spectroscopy; use traceable NMs to quantify influx and efflux rates in model aquatic species, including in a trophic chain; and employ both conventional measures of toxicological endpoints as well as the latest molecular ('omics') methods to quantify biological effects as well as identify new mechanisms for toxicity. Such information will be input into biotic ligand models for NMs classes that output anticipated EC50 and other outcomes given information about NM exposure and local water chemistry. Through its engagement with end-users the consortia will link its predictions of NM body burdens and toxicological outcomes to risk management frameworks useful in regulatory decision-making. |
| 资源类型: | 项目
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| 标识符: | http://119.78.100.158/handle/2HF3EXSE/103897
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| Appears in Collections: | 科学计划与规划
气候变化与战略
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作者单位: | University of Birmingham
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| Recommended Citation: | |
Jamie Lead. Manufactured nanoparticle bioavailability and environmental exposure (nanoBEE). 2009-01-01.
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