DOI: 10.1111/ele.12919
Scopus记录号: 2-s2.0-85041671593
论文题名: Competing for blood: the ecology of parasite resource competition in human malaria–helminth co-infections
作者: Budischak S.A. ; Wiria A.E. ; Hamid F. ; Wammes L.J. ; Kaisar M.M.M. ; van Lieshout L. ; Sartono E. ; Supali T. ; Yazdanbakhsh M. ; Graham A.L.
刊名: Ecology Letters
ISSN: 1461023X
EISSN: 1461-0248
出版年: 2018
卷: 21, 期: 4 起始页码: 536
结束页码: 545
语种: 英语
英文关键词: Ascaris lumbricoides
; co-infection interactions
; Hookworms
; Plasmodium falciparum
; Plasmodium vivax
; resource competition
; within-host ecology
Scopus关键词: Ancylostomatoidea
; Ascaris lumbricoides
; Mus
; Plasmodium falciparum
; Plasmodium vivax
; Vermes
英文摘要: Ecological theory suggests that co-infecting parasite species can interact within hosts directly, via host immunity and/or via resource competition. In mice, competition for red blood cells (RBCs) between malaria and bloodsucking helminths can regulate malaria population dynamics, but the importance of RBC competition in human hosts was unknown. We analysed infection density (i.e. the concentration of parasites in infected hosts), from a 2-year deworming study of over 4000 human subjects. After accounting for resource-use differences among parasites, we find evidence of resource competition, priority effects and a competitive hierarchy within co-infected individuals. For example reducing competition via deworming increased Plasmodium vivax densities 2.8-fold, and this effect is limited to bloodsucking hookworms. Our ecological, resource-based perspective sheds new light into decades of conflicting outcomes of malaria–helminth co-infection studies with significant health and transmission consequences. Beyond blood, investigating within-human resource competition may bring new insights for improving human health. © 2018 John Wiley & Sons Ltd/CNRS Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/107478
Appears in Collections: 气候减缓与适应
There are no files associated with this item.
作者单位: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, United States; Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia; Department of Medical Microbiology, Erasmus MC, Rotterdam, Netherlands
Recommended Citation:
Budischak S.A.,Wiria A.E.,Hamid F.,et al. Competing for blood: the ecology of parasite resource competition in human malaria–helminth co-infections[J]. Ecology Letters,2018-01-01,21(4)