globalchange  > 气候减缓与适应
DOI: 10.1111/ele.12890
Scopus记录号: 2-s2.0-85037337675
论文题名:
The impact of host genetic diversity on virus evolution and emergence
作者: Rodríguez-Nevado C.; Lam T.T.-Y.; Holmes E.C.; Pagán I.
刊名: Ecology Letters
ISSN: 1461023X
EISSN: 1461-0248
出版年: 2018
卷: 21, 期:2
起始页码: 253
结束页码: 263
语种: 英语
英文关键词: Biodiversity ; host genetic diversity ; parasite emergence ; rabies virus ; virus evolution
Scopus关键词: Rabies virus
英文摘要: Accumulating evidence indicates that biodiversity has an important impact on parasite evolution and emergence. The vast majority of studies in this area have only considered the diversity of species within an environment as an overall measure of biodiversity, overlooking the role of genetic diversity within a particular host species. Although theoretical models propose that host genetic diversity in part shapes that of the infecting parasite population, and hence modulates the risk of parasite emergence, this effect has seldom been tested empirically. Using Rabies virus (RABV) as a model parasite, we provide evidence that greater host genetic diversity increases both parasite genetic diversity and the likelihood of a host being a donor in RABV cross-species transmission events. We conclude that host genetic diversity may be an important determinant of parasite evolution and emergence. © 2017 John Wiley & Sons Ltd/CNRS
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/107499
Appears in Collections:气候减缓与适应

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作者单位: Centro de Biotecnología y Genómica de Plantas (Universidad Politécnica de Madrid – Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria), Madrid, Spain; State Key Laboratory of Emerging Infectious Diseases, Centre of Influenza Research, School of Public Health, The University of Hong Kong, Hong Kong; Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, University of Sydney, Sydney, NSW, Australia

Recommended Citation:
Rodríguez-Nevado C.,Lam T.T.-Y.,Holmes E.C.,et al. The impact of host genetic diversity on virus evolution and emergence[J]. Ecology Letters,2018-01-01,21(2)
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