DOI: 10.1111/ele.12726
Scopus记录号: 2-s2.0-85010341431
论文题名: A framework for how environment contributes to cancer risk
作者: Hochberg M.E. ; Noble R.J.
刊名: Ecology Letters
ISSN: 1461023X
EISSN: 1461-0248
出版年: 2017
卷: 20, 期: 2 起始页码: 117
结束页码: 134
语种: 英语
英文关键词: Ageing
; anthropogenic impact
; body size
; cancer risk
; environment
; epidemiology
; evolutionary mismatch
; global change
; longevity
; modern lifestyles
; mutagens
; pathogens
Scopus关键词: aging population
; anthropogenic effect
; body size
; cancer
; environmental conditions
; epidemiology
; evolutionary theory
; fitness
; global change
; human activity
; longevity
; metazoan
; pathogen
; Animalia
; Metazoa
; animal
; environment
; human
; human activities
; Neoplasms
; risk factor
; Animals
; Environment
; Human Activities
; Humans
; Neoplasms
; Risk Factors
英文摘要: Evolutionary theory explains why metazoan species are largely protected against the negative fitness effects of cancers. Nevertheless, cancer is often observed at high incidence across a range of species. Although there are many challenges to quantifying cancer epidemiology and assessing its causes, we claim that most modern-day cancer in animals – and humans in particular – are due to environments deviating from central tendencies of distributions that have prevailed during cancer resistance evolution. Such novel environmental conditions may be natural and/or of anthropogenic origin, and may interface with cancer risk in numerous ways, broadly classifiable as those: increasing organism body size and/or life span, disrupting processes within the organism, and affecting germline. We argue that anthropogenic influences, in particular, explain much of the present-day cancer risk across life, including in humans. Based on a literature survey of animal species and a parameterised mathematical model for humans, we suggest that combined risks of all cancers in a population beyond c. 5% can be explained to some extent by the influence of novel environments. Our framework provides a basis for understanding how natural environmental variation and human activity impact cancer risk, with potential implications for species ecology. © 2017 John Wiley & Sons Ltd/CNRS Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/107666
Appears in Collections: 气候减缓与适应
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作者单位: Intstitut des Sciences de l'Evolution de Montpellier, Université de Montpellier, Place E. Bataillon, CC065, Montpellier Cedex 5, France; Santa Fe Institute, 1399 Hyde Park Rd., Santa Fe, NM, United States
Recommended Citation:
Hochberg M.E.,Noble R.J.. A framework for how environment contributes to cancer risk[J]. Ecology Letters,2017-01-01,20(2)