DOI: 10.1111/ele.12639
Scopus记录号: 2-s2.0-84981524620
论文题名: Facilitation through altered resource availability in a mixed-species rodent malaria infection
作者: Ramiro R.S. ; Pollitt L.C. ; Mideo N. ; Reece S.E.
刊名: Ecology letters
ISSN: 14610248
EISSN: 1461-0248
出版年: 2016
卷: 19, 期: 9 起始页码: 1041
结束页码: 1050
语种: 英语
英文关键词: Co-infection
; facilitation
; genetically diverse infection
; Malaria
; Plasmodium chabaudi
; Plasmodium yoelii
; red blood cell
; reticulocyte
; species interactions
; virulence
Scopus关键词: animal
; biological model
; Coinfection
; erythrocyte
; genetics
; host parasite interaction
; malaria
; male
; mouse
; parasitology
; physiology
; Plasmodium chabaudi
; Plasmodium yoelii
; prevalence
; reproductive fitness
; Rodent Diseases
; veterinary
; Animals
; Coinfection
; Erythrocytes
; Genetic Fitness
; Host-Parasite Interactions
; Malaria
; Male
; Mice
; Models, Biological
; Plasmodium chabaudi
; Plasmodium yoelii
; Prevalence
; Rodent Diseases
; Plasmodium chabaudi
; Plasmodium falciparum
; Plasmodium yoelii
; Rodentia
英文摘要: A major challenge in disease ecology is to understand how co-infecting parasite species interact. We manipulate in vivo resources and immunity to explain interactions between two rodent malaria parasites, Plasmodium chabaudi and P. yoelii. These species have analogous resource-use strategies to the human parasites Plasmodium falciparum and P. vivax: P. chabaudi and P. falciparum infect red blood cells (RBC) of all ages (RBC generalist); P. yoelii and P. vivax preferentially infect young RBCs (RBC specialist). We find that: (1) recent infection with the RBC generalist facilitates the RBC specialist (P. yoelii density is enhanced ~10 fold). This occurs because the RBC generalist increases availability of the RBC specialist's preferred resource; (2) co-infections with the RBC generalist and RBC specialist are highly virulent; (3) and the presence of an RBC generalist in a host population can increase the prevalence of an RBC specialist. Thus, we show that resources shape how parasite species interact and have epidemiological consequences. © 2016 The Authors. Ecology Letters published by CNRS and John Wiley & Sons Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/107731
Appears in Collections: 气候减缓与适应
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作者单位: Institutes of Evolutionary Biology, and Immunology and Infection Research, University of Edinburgh, Edinburgh, EH9 3JFL, UK; Centre for Immunity, Infection & Evolution, School of Biological Sciences, Ashworth Laboratories, University of Edinburgh, Edinburgh, EH9 3JFL, UK; Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, Canada
Recommended Citation:
Ramiro R.S.,Pollitt L.C.,Mideo N.,et al. Facilitation through altered resource availability in a mixed-species rodent malaria infection[J]. Ecology letters,2016-01-01,19(9)