DOI: 10.1111/ele.12490
Scopus记录号: 2-s2.0-84941023592
论文题名: Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens
作者: Vijendravarma R.K. ; Narasimha S. ; Chakrabarti S. ; Babin A. ; Kolly S. ; Lemaitre B. ; Kawecki T.J.
刊名: Ecology Letters
ISSN: 1461023X
EISSN: 1461-0248
出版年: 2015
卷: 18, 期: 10 起始页码: 1078
结束页码: 1086
语种: 英语
英文关键词: Drosophila
; Pseudomonas entomophila
; Adaptation
; Enteric infections
; Experimental evolution
; Host-parasite interactions
; Innate immunity
; Nutritional stress
; Stress tolerance
; Trade-offs
Scopus关键词: adaptation
; bacterium
; experimental study
; fly
; gastroenteritis
; host-parasite interaction
; immune response
; infectivity
; innate behavior
; malnutrition
; nutritional disorder
; nutritional requirement
; physiological response
; stress resistance
; tolerance
; trade-off
; Animalia
; Bacteria (microorganisms)
; Drosophila melanogaster
; Pseudomonas entomophila
; adaptation
; animal
; bacterial load
; disease predisposition
; Drosophila melanogaster
; evolution
; immunology
; intestine
; larva
; malnutrition
; microbiology
; physiology
; Pseudomonas
; Adaptation, Physiological
; Animals
; Bacterial Load
; Biological Evolution
; Disease Susceptibility
; Drosophila melanogaster
; Intestines
; Larva
; Malnutrition
; Pseudomonas
英文摘要: The animal gut plays a central role in tackling two common ecological challenges, nutrient shortage and food-borne parasites, the former by efficient digestion and nutrient absorption, the latter by acting as an immune organ and a barrier. It remains unknown whether these functions can be independently optimised by evolution, or whether they interfere with each other. We report that Drosophila melanogaster populations adapted during 160 generations of experimental evolution to chronic larval malnutrition became more susceptible to intestinal infection with the opportunistic bacterial pathogen Pseudomonas entomophila. However, they do not show suppressed immune response or higher bacterial loads. Rather, their increased susceptibility to P. entomophila is largely mediated by an elevated predisposition to loss of intestinal barrier integrity upon infection. These results may reflect a trade-off between the efficiency of nutrient extraction from poor food and the protective function of the gut, in particular its tolerance to pathogen-induced damage. © 2015 John Wiley & Sons Ltd/CNRS. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/107858
Appears in Collections: 气候减缓与适应
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作者单位: Department of Ecology and Evolution, University of Lausanne, Lausanne, Switzerland; Global Health Institute, EPFL, Lausanne, Switzerland; INRA, Université Nice Sophia Antipolis, CNRS, UMR 1355-7254 Institut Sophia Agrobiotech, France
Recommended Citation:
Vijendravarma R.K.,Narasimha S.,Chakrabarti S.,et al. Gut physiology mediates a trade-off between adaptation to malnutrition and susceptibility to food-borne pathogens[J]. Ecology Letters,2015-01-01,18(10)