DOI: 10.1111/ele.12534
Scopus记录号: 2-s2.0-84946224115
论文题名: Bottom-up regulation of malaria population dynamics in mice co-infected with lung-migratory nematodes
作者: Griffiths E.C. ; Fairlie-Clarke K. ; Allen J.E. ; Metcalf C.J.E. ; Graham A.L.
刊名: Ecology Letters
ISSN: 1461023X
EISSN: 1461-0248
出版年: 2015
卷: 18, 期: 12 起始页码: 1387
结束页码: 1396
语种: 英语
英文关键词: Co-infection
; Community ecology
; Effective propagation
; Immune profile
; Parasite ecology
; Predator community
; Resource regulation
; Target cell limitation
Scopus关键词: bottom-up control
; cells and cell components
; community ecology
; epidemiology
; experimental study
; immune response
; infectivity
; malaria
; nematode
; population dynamics
; predator-prey interaction
; quantitative analysis
; rodent
; Mus
; Nematoda
; Nippostrongylus brasiliensis
; Plasmodium chabaudi
; animal
; Bagg albino mouse
; female
; immunology
; innate immunity
; malaria
; mixed infection
; mouse
; Nippostrongylus
; parasitology
; physiology
; Plasmodium chabaudi
; population dynamics
; rodent disease
; strongyle infection
; Animals
; Coinfection
; Female
; Immunity, Innate
; Malaria
; Mice
; Mice, Inbred BALB C
; Nippostrongylus
; Plasmodium chabaudi
; Population Dynamics
; Rodent Diseases
; Strongylida Infections
英文摘要: When and how populations are regulated by bottom up vs. top down processes, and how those processes are affected by co-occurring species, are poorly characterised across much of ecology. We are especially interested in the community ecology of parasites that must share a host. Here, we quantify how resources and immunity affect parasite propagation in experiments in near-replicate 'mesocosms'' - i.e. mice infected with malaria (Plasmodium chabaudi) and nematodes (Nippostrongylus brasiliensis). Nematodes suppressed immune responses against malaria, and yet malaria populations were smaller in co-infected hosts. Further analyses of within-host epidemiology revealed that nematode co-infection altered malaria propagation by suppressing target cell availability. This is the first demonstration that bottom-up resource regulation may have earlier and stronger effects than top-down immune mechanisms on within-host community dynamics. Our findings demonstrate the potential power of experimental ecology to disentangle mechanisms of population regulation in complex communities. © 2015 John Wiley & Sons Ltd/CNRS. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/107954
Appears in Collections: 气候减缓与适应
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作者单位: Department of Entomology, Gardner Hall, Derieux Place, Raleigh, NC, United States; Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical and Veterinary Life Sciences, University of Glasgow, Glasgow, United Kingdom; Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom; Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, United States; Fogarty International Center, National Institutes of Health, Bethesda, MD, United States
Recommended Citation:
Griffiths E.C.,Fairlie-Clarke K.,Allen J.E.,et al. Bottom-up regulation of malaria population dynamics in mice co-infected with lung-migratory nematodes[J]. Ecology Letters,2015-01-01,18(12)