DOI: 10.1016/j.jcou.2018.08.015
Scopus记录号: 2-s2.0-85051992348
论文题名: Zein/diclofenac sodium coprecipitation at micrometric and nanometric range by supercritical antisolvent processing
作者: Franco P. ; Reverchon E. ; De Marco I.
刊名: Journal of CO2 Utilization
ISSN: 22129820
出版年: 2018
卷: 27 起始页码: 366
结束页码: 373
语种: 英语
英文关键词: Drug release
; Microparticles
; Nanoparticles
; SAS characteristic times
; Supercritical antisolvent coprecipitation
; Zein
Scopus关键词: Controlled drug delivery
; Coprecipitation
; Nanoparticles
; Sodium
; Targeted drug delivery
; Zein
; Diclofenac sodium
; Drug release
; Micro-particles
; Nanometric ranges
; Nanoparticles formations
; SAS characteristic times
; Supercritical antisolvent process
; Supercritical antisolvents
; Supercritical fluid extraction
英文摘要: In this work, the supercritical antisolvent (SAS) process is proposed to coprecipitate zein with diclofenac sodium (a model drug). In the first part of this paper, the proper conditions, in terms of pressure, temperature and concentration, for the attainment of zein microparticles, were detected. At 90 bar, 40 °C and 50 mg/mL, microparticles with a mean diameter of 4.19 μm were obtained. The coprecipitation with diclofenac sodium at different polymer/drug ratio and concentration in the liquid solution was successfully performed and, with the support of the drug release analyses, the coprecipitation mechanisms (both in the case of microparticles and nanoparticles formation) were postulated. © 2018 Elsevier Ltd. All rights reserved. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/111784
Appears in Collections: 气候减缓与适应
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作者单位: Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, SA, 84084, Italy
Recommended Citation:
Franco P.,Reverchon E.,De Marco I.. Zein/diclofenac sodium coprecipitation at micrometric and nanometric range by supercritical antisolvent processing[J]. Journal of CO2 Utilization,2018-01-01,27