DOI: 10.1016/j.jcou.2018.09.004
Scopus记录号: 2-s2.0-85053146068
论文题名: Gas antisolvent fractionation based optical resolution of ibuprofen with enantiopure phenylglycinol
作者: Lorincz L. ; Tóth Á. ; Kondor L. ; Kéri O. ; Madarász J. ; Varga E. ; Székely E.
刊名: Journal of CO2 Utilization
ISSN: 22129820
出版年: 2018
卷: 27 起始页码: 493
结束页码: 499
语种: 英语
英文关键词: Crystallization
; Enantiomer
; Gas antisolvent process
; Process intensification
; Scalemic mixture
; Supercritical carbon dioxide
Scopus关键词: Carbon dioxide
; Carbon dioxide process
; Crystallization
; Enantiomers
; Fractionation
; Mixtures
; Precipitation (chemical)
; Diastereomeric salts
; Enantiomeric purity
; Equilibration time
; Gas anti-solvent process
; Operational parameters
; Optical resolution
; Process intensification
; Supercritical carbon dioxides
; Supercritical fluid extraction
英文摘要: Optical resolution is still the dominant route to obtaining enantiopure active ingredients. The traditional methods require large organic solvent quantities and long processing times. Antisolvent fractionation with supercritical carbon dioxide offers intensified processing by drastically reducing the time requirement of the diastereomeric salt precipitation. A novel optical resolution of ibuprofen was developed and optimized with phenylglycinol as a resolving agent and gas antisolvent fractionation as the separation method. Above the critical values of certain operational parameters (carbon dioxide to methanol ratio, apparent diastereomeric salt concentration, equilibration time, the relative volume of the extracting fluid) the selectivity was roughly constant, the optical resolution is robust. The scalemic mixtures were purified by repeated resolution and enantiomeric purities above 99% were reached in three consecutive steps. © 2018 Elsevier Ltd. All rights reserved.. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/111786
Appears in Collections: 气候减缓与适应
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作者单位: Budapest University of Technology and Economics, Department of Chemical and Environmental Process Engineering, Muegyetem rkp 3., Budapest, H-1111, Hungary; Budapest University of Technology and Economics, Department of Inorganic and Analytical Chemistry, Muegyetem rkp 3., Budapest, H-1111, Hungary; Cyclolab Ltd., Illatos út 7., Budapest, H-1097, Hungary
Recommended Citation:
Lorincz L.,Tóth Á.,Kondor L.,et al. Gas antisolvent fractionation based optical resolution of ibuprofen with enantiopure phenylglycinol[J]. Journal of CO2 Utilization,2018-01-01,27