DOI: 10.1016/j.jcou.2018.05.011
Scopus记录号: 2-s2.0-85047157375
论文题名: Application of Box-Behnken design for processing of mefenamic acid-paracetamol cocrystals using gas anti-solvent (GAS) process
作者: Wichianphong N. ; Charoenchaitrakool M.
刊名: Journal of CO2 Utilization
ISSN: 22129820
出版年: 2018
卷: 26 起始页码: 212
结束页码: 220
语种: 英语
英文关键词: Box-Behnken
; Drug-drug cocrystal
; GAS process
; Mefenamic acid
; Paracetamol
Scopus关键词: Dissolution
; Box-Behnken
; Box-Behnken experimental design
; Co-crystals
; Gas anti-solvent process
; Mefenamic acid
; Paracetamol
; Poorly water-soluble drugs
; Slow evaporation techniques
; Gases
英文摘要: The present work deals with the preparation of drug-drug cocrystals of mefenamic acid (MEF) with paracetamol (PAR) using gas antisolvent (GAS) process with an aim to improve the dissolution rate of MEF. Box-Behnken experimental design was used to optimize the GAS process variables for minimal dissolution time of MEF. A mathematical model was developed to study the effects of operating temperature, PAR-to-MEF molar ratio and %MEF saturation in the ranges of 25°C-45°C, 3:1-5:1 and 70-90%, respectively. PAR-to-MEF ratio and %MEF saturation were found to be the main parameters affecting the dissolution time. The fastest dissolution time (t63.2), 11.38min, was obtained at the optimal conditions of a temperature of 34.9°C, PAR-to-MEF ratio of 4.3:1 and MEF saturation of 86.8%. Optimized cocrystals by GAS showed that the dissolution rate of MEF improved by 6.0, 5.3 and 2.3-fold when compared to pure MEF, sieved cocrystals prepared by a traditional slow evaporation technique and sieved marketed combination drugs, respectively. GAS cocrystallization thus offers an efficient way to enhance the dissolution rate of the poorly water-soluble drug. © 2018 Published by Elsevier Ltd. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/111833
Appears in Collections: 气候减缓与适应
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作者单位: Department of Chemical Engineering, Faculty of Engineering, Kasetsart University, Bangkok, 10900, Thailand; Center for Advanced Studies in Nanotechnology for Chemical, Food and Agricultural Industries, KU Institute for Advanced Studies, Kasetsart University, Bangkok, 10900, Thailand; NANOTEC-KU-Center of Excellence on Nanoscale Materials Design for Green Nanotechnology, Kasetsart University, Bangkok, 10900, Thailand
Recommended Citation:
Wichianphong N.,Charoenchaitrakool M.. Application of Box-Behnken design for processing of mefenamic acid-paracetamol cocrystals using gas anti-solvent (GAS) process[J]. Journal of CO2 Utilization,2018-01-01,26