DOI: 10.1016/j.jcou.2018.04.007
Scopus记录号: 2-s2.0-85045307745
论文题名: CO2 assisted deposition of R/S-ibuprofen on different porous carrier materials: Influence of carrier properties on loading and dissolution behavior
作者: Reiser S. ; Shaban M. ; Weber A. ; Türk M.
刊名: Journal of CO2 Utilization
ISSN: 22129820
出版年: 2018
卷: 25 起始页码: 216
结束页码: 225
语种: 英语
英文关键词: Carrier materials
; CO2
; Controlled particle deposition
; Dissolution
; Ibuprofen
Scopus关键词: Biochemistry
; Carbon dioxide
; Controlled drug delivery
; Deposition
; Pore size
; Specific surface area
; Spray pyrolysis
; Capillary condensation
; Carrier material
; Dissolution behavior
; Gastrointestinal tract
; Ibuprofen
; Multilayer formation
; Particle depositions
; Poorly water-soluble drugs
; Dissolution
英文摘要: With regard to bioavailability of poorly water-soluble drugs a big goal in research is to improve their dissolution behavior in the gastrointestinal tract. One suitable way to enhance the bioavailability is the use of drug loaded carrier materials. However, the effect of carrier properties such as specific surface area, pore size and pore volume on the dissolution of drugs is not well known yet. To investigate this, carrier materials with defined properties were produced by Salt Assisted Spray Pyrolysis (SASP) and loaded with racemic ibuprofen by the Controlled Particle Deposition (CPD) process. Their loadings and dissolution rates were compared to those of MCM-41 and SBA-15. It was found that the ibuprofen loading on the SASP carrier materials is lower due to their smaller specific surface areas, whereas their dissolution rates were higher in comparison to CPD processed MCM-41 and SBA-15. Furthermore, it was observed that pore size and pore volume influence the loading capacity of carrier materials. Wider mesopores lead to multilayer formation where crystalline ibuprofen structures were detected by XRD analysis. N2-adsorption/desorption experiments at T =77K on the CPD processed carriers lead to the assumption that the small mesopores of MCM-41 or SBA-15 were occupied by ibuprofen due to the shift of the typical capillary condensation step at p/p0=0.3-0.4 (untreated material) towards lower relative pressures of the CPD processed carriers. © 2018 Elsevier Ltd. All rights reserved. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/111899
Appears in Collections: 气候减缓与适应
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作者单位: Institute for Technical Thermodynamics and Refrigeration, Karlsruhe Institute of Technology (KIT), Engler-Bunte-Ring 21, Karlsruhe, D - 76131, Germany; Institute of Particle Technology, Technical University of Clausthal, Leibnizstraße 19, Clausthal-Zellerfeld, D-38678, Germany
Recommended Citation:
Reiser S.,Shaban M.,Weber A.,et al. CO2 assisted deposition of R/S-ibuprofen on different porous carrier materials: Influence of carrier properties on loading and dissolution behavior[J]. Journal of CO2 Utilization,2018-01-01,25