DOI: 10.1016/j.jcou.2018.04.006
Scopus记录号: 2-s2.0-85045513366
论文题名: Supercritical assisted process for the efficient production of liposomes containing antibiotics for ocular delivery
作者: Campardelli R. ; Trucillo P. ; Reverchon E.
刊名: Journal of CO2 Utilization
ISSN: 22129820
出版年: 2018
卷: 25 起始页码: 235
结束页码: 241
语种: 英语
英文关键词: Antibiotics
; Drug carriers
; Liposomes
; Nanomedicine
; Ocular delivery
; Process optimization
; Supercritical fluids
Scopus关键词: Antibiotics
; Efficiency
; Effluent treatment
; Encapsulation
; Liposomes
; Medical nanotechnology
; Optimization
; Supercritical fluids
; Targeted drug delivery
; Continuous process
; Conventional techniques
; Drug carrier
; Drug concentration
; Drug release kinetics
; Encapsulation efficiency
; Liposome formation
; Ocular delivery
; Controlled drug delivery
英文摘要: Conventional techniques developed for the production of liposomes for ocular delivery show low encapsulation efficiencies (EE). In this work, a supercritical CO2 based one-step continuous process, named Supercritical Assisted Liposome formation (SuperLip), was used for the production of liposomes to deliver ophthalmic antibiotics, such as ampicillin and ofloxacin. Micrometric and sub-micrometric liposomes with mean diameters in the range from 280 ± 104 nm to 1.76 ± 0.79 μm were successfully produced using drug concentrations in the range from 1% to 6% w/w and water to lipid ratios from 1.7 mg/g to 25 mg/g. Encapsulation efficiencies up to 97% and 99% were obtained for ofloxacin and ampicillin respectively. Storage stability and drug release kinetics of produced liposomes were also studied. Liposomes were stable for at least 3 months, with negligible drug leakage during storage time. At 37 °C ofloxacin and ampicillin were released in a controlled manner within 3 and 4 h respectively. © 2018 Elsevier Ltd. All rights reserved. Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/111915
Appears in Collections: 气候减缓与适应
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作者单位: Department of Industrial Engineering, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, SA, 84084, Italy
Recommended Citation:
Campardelli R.,Trucillo P.,Reverchon E.. Supercritical assisted process for the efficient production of liposomes containing antibiotics for ocular delivery[J]. Journal of CO2 Utilization,2018-01-01,25