DOI: 10.1016/j.watres.2018.08.017
Scopus记录号: 2-s2.0-85053025394
论文题名: Environmental fate and ecotoxicological effects of antiretrovirals: A current global status and future perspectives
作者: Ncube S. ; Madikizela L.M. ; Chimuka L. ; Nindi M.M.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 145 起始页码: 231
结束页码: 247
语种: 英语
英文关键词: Antiretroviral combination therapy
; Antiretrovirals
; Environmental samples
; HIV/AIDS
; Predicted environmental concentration
; Predicted no effect concentration
Scopus关键词: Drug interactions
; Effluents
; Metabolites
; Surface waters
; Toxicity
; Viruses
; Wastewater treatment
; Antiretrovirals
; Combination therapy
; Environmental sample
; HIV/AIDS
; Predicted environmental concentrations
; Predicted no-effect concentrations
; Diseases
; concentration (composition)
; ecotoxicology
; environmental assessment
; environmental fate
; feces
; future prospect
; global perspective
; human immunodeficiency virus
; metabolite
; phytotoxicity
; runoff
; surface water
; toxicity
; urine
; wastewater treatment plant
; Human immunodeficiency virus
英文摘要: The therapeutic efficacy of antiretroviral drugs as well as challenges and side effects against the human immunodeficiency virus is well documented and reviewed. Evidence is available in literature indication that antiretrovirals are only partially transformed and become completely excreted from the human body in their original form and/or as metabolites in urine and feces. The possibility of massive release of antiretrovirals through human excreta that enters surface water through surface runoff and wastewater treatment plant effluents is now of environmental concern because the public might be experiencing chronic exposure to antiretrovirals. The primary concern of this review is limited data concerning environmental fate and ecotoxicity of antiretrovirals and their metabolites. The review aims to provide a comprehensive insight into the evaluation of antiretrovirals in environmental samples. The objective is therefore to assess the extent of analysis of antiretrovirals in environmental samples and also look at strategies including instrumentation and predictive models that have been reported in literature on the fate and ecotoxicological effects due to presence of antiretrovirals in different environmental compartments. The review also looks at current challenges and offers possible areas of exploration that could help minimize the presence of antiretrovirals in the environment. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112453
Appears in Collections: 气候减缓与适应
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作者单位: Department of Chemistry, University of South Africa, Private Bag X6, Florida, 1710, South Africa; Department of Chemistry, Durban University of Technology, P.O. Box 1334, Durban, 4000, South Africa; Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Private Bag X3, Johannesburg, 2050, South Africa
Recommended Citation:
Ncube S.,Madikizela L.M.,Chimuka L.,et al. Environmental fate and ecotoxicological effects of antiretrovirals: A current global status and future perspectives[J]. Water Research,2018-01-01,145