DOI: 10.1016/j.watres.2018.07.032
Scopus记录号: 2-s2.0-85050104283
论文题名: Fundamental study of the ultrasonic induced degradation of the popular antihistamine, diphenhydramine (DPH)
作者: Cui D. ; Mebel A.M. ; Arroyo-Mora L.E. ; Zhao C. ; De Caprio A. ; O'Shea K.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 144 起始页码: 265
结束页码: 273
语种: 英语
英文关键词: Advanced oxidation
; Degradation
; Diphenhydramine
; Pyrolysis
; Ultrasound
Scopus关键词: Arsenic compounds
; Degradation
; Dyes
; Kinetics
; Pyrolysis
; Rate constants
; Solutions
; Ultrasonics
; Advanced oxidation
; Computational studies
; Diphenhydramine
; Partition coefficient
; Pseudo first-order kinetics
; Surface water sources
; Ultrasonic degradation
; Ultrasound irradiation
; Surface waters
; coumarin
; diphenhydramine
; hydrogen
; hydroxyl radical
; reactive oxygen metabolite
; aqueous solution
; chemical reaction
; concentration (composition)
; degradation
; drug
; experimental study
; health impact
; hydroxyl radical
; partitioning
; pyrolysis
; reaction kinetics
; scavenging (chemistry)
; surface water
; ultraviolet radiation
; adsorption
; Article
; desorption
; drug degradation
; observed association rate constant
; priority journal
; pyrolysis
; ultrasound
英文摘要: Diphenhydramine (DPH) the active ingredient in Benadryl, has been detected in streams, rivers and other surface water sources. As a bioactive compound, DPH impacts human health even at low concentrations. Ultrasonic irradiation at 640 kHz leads to the rapid degradation of DPH in aqueous solution. Radical scavenging experiments and detailed product studies indicate the DPH degradation involves direct pyrolysis and degradation reactions mediated by the hydroxyl radicals produced during cavitation. The degradation can be modeled by pseudo-first order kinetics yielding rate constants k of 0.210, 0.130, 0.082, 0.050, 0.035, 0.023 min−1 at the initial concentrations of 2.8, 5.2, 13.9, 27.0, 61.0, 160.0 μmol L−1, respectively. The degradation process follows the Langmuir-Hinshelwood (heterogeneous) model with a partition coefficient, KL-H = 0.06 μmol·L−1and reactivity constant kr = 1.96 μmol min−1·L−1. A competition kinetic study conducted employing the hydroxyl radical trap, coumarin, illustrates that DPH was degraded primarily by hydroxyl radical mediated processes. Computational studies employing Gaussian 09 basis set provide fundamental insight into the partitioning of the reaction pathways and the degradation mechanisms. The study demonstrates the ultrasonic degradation of DPH is rapid, follows simple kinetic expressions and is accurately modeled using computational methods. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112533
Appears in Collections: 气候减缓与适应
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作者单位: Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, United States; Department of Forensic and Investigative Science, West Virginia University, Morgantown, WV 26506, United States
Recommended Citation:
Cui D.,Mebel A.M.,Arroyo-Mora L.E.,et al. Fundamental study of the ultrasonic induced degradation of the popular antihistamine, diphenhydramine (DPH)[J]. Water Research,2018-01-01,144