DOI: 10.1016/j.watres.2018.07.035
Scopus记录号: 2-s2.0-85053073350
论文题名: Cytostatic drug removal using electrochemical oxidation with BDD electrode: Degradation pathway and toxicity
作者: Siedlecka E.M. ; Ofiarska A. ; Borzyszkowska A.F. ; Białk-Bielińska A. ; Stepnowski P. ; Pieczyńska A.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 144 起始页码: 235
结束页码: 245
语种: 英语
英文关键词: Anticancer drug
; Degradation pathway
; Eco-toxicity
; Electrochemical oxidation
Scopus关键词: Boolean functions
; Degradation
; Drug products
; Efficiency
; Electrochemical electrodes
; Organic carbon
; Rate constants
; Toxicity
; 5-fluorouracil (5-FU)
; Anticancer drug
; Boron-doped diamond electrodes
; Degradation pathways
; Ecotoxicity
; Electrochemical treatments
; Mineralization current efficiencies
; Pseudo first order rate constants
; Electrochemical oxidation
; cancer
; decomposition
; degradation
; drug
; ecotoxicology
; electrochemical method
; electrode
; electrokinesis
; mineralization
; optimization
; oxidation
; pollutant removal
; total organic carbon
; toxicity
; Lemna minor
英文摘要: In the presented study, electrochemical oxidation of five anticancer drugs (5-fluorouracil (5-FU), ifosfamide (IF), cyclophosphamide (CF), methotrexate (MTX), imatinib (IMB)) using boron doped diamond (BDD) electrode was investigated. In the first step the operating parameters of electrolysis were optimized. Studies have demonstrated a significant influence of applying current density, temperature, pH of solution and initial concentration of 5-FU on the process efficiency. A comparison of the decomposition rate of all the tested drugs showed a decrease in the pseudo-first order rate constants in the following order: k(IMB) > k(MTX) > k(CF) ≈ k(IF) > k(5-FU). Mineralization current efficiency (MCE) was determined for all the drugs based on the removal amount of total organic carbon (TOC) and their values decreased in the same order as values of drug degradation rate k. Based on the identified degradation products, electrochemical oxidation pathways of the decomposed drugs were proposed. In the case of CF, IF and 5-FU the degradation process occurred mainly through ketonization, hydroxylation and dehalogenation, while MTX and IMB were decomposed by attack of hydroxyl radicals on benzyl position in parent compounds. An important part of the research was the evaluation of eco-toxicity of electrochemically treated drug solutions against Lemna minor. Toxicity of initial 5-FU and MTX solutions towards L. minor were observed but after electrochemical treatment its toxicity decreased. The opposite trend was observed for CF and IF. In this case no significant toxicity was observed for the initial solutions of these drugs, while after electrochemical treatment an increase in growth inhibition of L. minor was found. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112534
Appears in Collections: 气候减缓与适应
There are no files associated with this item.
作者单位: Department of Environmental Technology, Faculty of Chemistry, University of Gdańsk, 63Wita Stwosza Str., Gdańsk, 80-308, Poland; Department of Environmental Analytics, Faculty of Chemistry, University of Gdańsk, 63Wita Stwosza Str., Gdańsk, 80-308, Poland
Recommended Citation:
Siedlecka E.M.,Ofiarska A.,Borzyszkowska A.F.,et al. Cytostatic drug removal using electrochemical oxidation with BDD electrode: Degradation pathway and toxicity[J]. Water Research,2018-01-01,144