DOI: 10.1016/j.watres.2018.05.008
Scopus记录号: 2-s2.0-85047978678
论文题名: Trimeprazine is enantioselectively degraded by an activated sludge in ready biodegradability test conditions
作者: Escuder-Gilabert L. ; Martín-Biosca Y. ; Perez-Baeza M. ; Sagrado S. ; Medina-Hernández M.J.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 141 起始页码: 57
结束页码: 64
语种: 英语
英文关键词: Batch experiment
; Biodegradability test
; Curve fitting
; Enantioselectivity
; Precision
; Trimeprazine
Scopus关键词: Biodegradability
; Biodegradation
; Enantiomers
; Enantioselectivity
; Waste treatment
; Wastewater treatment
; Water treatment
; Batch experiments
; Biodegradability tests
; Chiral stationary phase
; Concentration levels
; Enantiomeric fractions
; Precision
; Precision studies
; Trimeprazine
; Curve fitting
; acetonitrile
; alimemazine
; cellulose
; sodium chlorate
; alimemazine
; antipruritic agent
; activated sludge
; Article
; biodegradability
; biodegradation
; biomass production
; concentration (parameters)
; enantiomer
; enantiomeric ratio
; enantioselectivity
; high performance liquid chromatography
; measurement repeatability
; priority journal
; racemic mixture
; waste water treatment plant
; bioremediation
; chemistry
; metabolism
; sewage
; stereoisomerism
; water pollutant
; Activated Sludge
; Biodegradability
; Biodegradation
; Concentration
; Effluent Treatment
; Experimentation
; Precision
; Water Treatment
; Antipruritics
; Biodegradation, Environmental
; Chromatography, High Pressure Liquid
; Sewage
; Stereoisomerism
; Trimeprazine
; Water Pollutants, Chemical
英文摘要: A great number of available pharmaceuticals are chiral compounds. Although they are usually manufactured as racemic mixtures, they can be enantioselectively biodegraded as a result of microbial processes. In this paper, a biodegradability assay in similar conditions to those recommended in OECD tests of enantiomers of trimeprazine (a phenothiazine employed as a racemate) is carried out. Experiments were performed in batch mode using a minimal salts medium inoculated with an activated sludge (collected from a Valencian Waste Water Treatment Plant, WWTP) and supplemented with the racemate. The concentration of the enantiomers of trimeprazine were monitored by means of a chiral HPLC method using a cellulose-based chiral stationary phase and 0.5 M NaClO4/acetonitrile (60:40, v/v) mobile phases. Experiments were performed at three concentration levels of the racemate. In parallel, the optical density at 600 nm (OD600) was measured to control the biomass growth and to connect it with enantioselectivity. The calculated enantiomeric fractions (EF) offer the first evidence of enantioselective biodegradation of trimeprazine. A simplified Monod equation was used as a curve fitting approach for concentration (S), biodegradation (BD), and for the first time, EF experimental data in order to expand the usefulness of the results. Precision studies on S (repeatability conditions) and, for the first time, EF (intermediate precision conditions) were also performed. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112670
Appears in Collections: 气候减缓与适应
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作者单位: Departamento de Química Analítica, Universitat de València, Burjassot, Valencia, Spain; Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València, Universitat de València, Burjassot, Valencia, Spain
Recommended Citation:
Escuder-Gilabert L.,Martín-Biosca Y.,Perez-Baeza M.,et al. Trimeprazine is enantioselectively degraded by an activated sludge in ready biodegradability test conditions[J]. Water Research,2018-01-01,141