DOI: 10.1016/j.watres.2018.04.005
Scopus记录号: 2-s2.0-85047445458
论文题名: Modeling the exposure of wild fish to endocrine active chemicals: Potential linkages of total estrogenicity to field-observed intersex
作者: Arlos M.J. ; Parker W.J. ; Bicudo J.R. ; Law P. ; Hicks K.A. ; Fuzzen M.L.M. ; Andrews S.A. ; Servos M.R.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 139 起始页码: 187
结束页码: 197
语种: 英语
英文关键词: Estrogen
; Exposure assessment
; Intersex
; Rainbow darter
; Wastewater
; Water quality model
Scopus关键词: Chemical detection
; Fish
; Rivers
; Toxicity
; Wastewater
; Wastewater treatment
; Water quality
; Estrogen
; Exposure assessment
; Intersex
; Rainbow darter
; Water quality modeling
; River pollution
; chloride
; endocrine disruptor
; estradiol
; estrone
; ethinylestradiol
; river water
; water
; endocrine disruptor
; estradiol
; estrogen
; estrone
; ethinylestradiol
; chemical pollutant
; concentration (composition)
; estrogenic compound
; European Union
; hydrological modeling
; intersexual interaction
; modeling
; perciform
; pollution exposure
; wastewater
; water quality
; wild population
; adult
; Article
; biodegradation
; calibration
; concentration (parameters)
; controlled study
; environmental exposure
; female
; fish
; geometry
; intersex
; male
; nonhuman
; Ontario
; priority journal
; water quality
; water standard
; wild animal
; animal
; chemically induced
; disorder of sex development
; perch
; river
; theoretical model
; toxicity
; waste water
; water pollutant
; Canada
; Grand River [Ontario]
; Ontario [Canada]
; Etheostoma caeruleum
; Animals
; Disorders of Sex Development
; Endocrine Disruptors
; Estradiol
; Estrogens
; Estrone
; Ethinyl Estradiol
; Female
; Male
; Models, Theoretical
; Ontario
; Perches
; Rivers
; Waste Water
; Water Pollutants, Chemical
英文摘要: Decades of studies on endocrine disruption have suggested the need to manage the release of key estrogens from municipal wastewater treatment plants (WWTP). However, the proposed thresholds are below the detection limits of most routine chemical analysis, thereby restricting the ability of watershed managers to assess the environmental exposure appropriately. In this study, we demonstrated the utility of a mechanistic model to address the data gaps on estrogen exposure. Concentrations of the prominent estrogenic contaminants in wastewaters (estrone, estradiol, and ethinylestradiol) were simulated in the Grand River in southern Ontario (Canada) for nine years, including a period when major WWTP upgrades occurred. The predicted concentrations expressed as total estrogenicity (E2 equivalent concentrations) were contrasted to a key estrogenic response (i.e., intersex) in rainbow darter (Etheostoma caeruleum), a wild sentinel fish species. A predicted total estrogenicity in the river of ≥10 ng/L E2 equivalents was associated with high intersex incidence and severity, whereas concentrations <0.1 ng/L E2 equivalents were associated with minimal intersex expression. Exposure to a predicted river concentration of 0.4 ng/L E2 equivalents, the environmental quality standard (EQS) proposed by the European Union for estradiol, was associated with 34% (95% CI:30–38) intersex incidence and a very low severity score of 0.6 (95% CI:0.5–0.7). This exposure is not predicted to cause adverse effects in rainbow darter. The analyses completed in this study were only based on the predicted presence of three major estrogens (E1, E2, EE2), so caution must be exercised when interpreting the results. Nevertheless, this study illustrates the use of models for exposure assessment, especially when measured data are not available. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112738
Appears in Collections: 气候减缓与适应
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作者单位: Department of Biology, University of Waterloo, Waterloo, ON N2L 3G1, Canada; Department of Civil and Environmental Engineering, University of WaterlooON N2L 3G1, Canada; Region of Waterloo, Kitchener, Ontario N2G 4J3, Canada; Department of Biology, McMaster University, Hamilton, ON L8S 4L8, Canada; Department of Civil Engineering, University of Toronto, Toronto, ON M5S 1S4, Canada
Recommended Citation:
Arlos M.J.,Parker W.J.,Bicudo J.R.,et al. Modeling the exposure of wild fish to endocrine active chemicals: Potential linkages of total estrogenicity to field-observed intersex[J]. Water Research,2018-01-01,139