DOI: 10.1016/j.watres.2018.03.071
Scopus记录号: 2-s2.0-85047407703
论文题名: Degradation and metabolite formation of 17ß-estradiol-3-glucuronide and 17ß-estradiol-3-sulphate in river water and sediment
作者: Ma L. ; Yates S.R.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 139 起始页码: 1
结束页码: 9
语种: 英语
英文关键词: 17ß-estradiol-3-glucuronide
; 17ß-estradiol-3-sulphate
; Degradation
; Metabolites
; River water
; Sediment
Scopus关键词: Biomolecules
; Degradation
; Esters
; Metabolites
; Population statistics
; Rivers
; Sediments
; Sulfur compounds
; Biodegradation pathways
; Degradation mechanism
; First order kinetics
; Glucuronides
; High population density
; River water
; Spiking concentration
; Sulphates
; Biodegradation
; 17beta estradiol 3 glucuronide
; 17beta estradiol 3 sulphate
; 6 ketoestrone
; conjugated estrogen
; delta 9(11) dehydroestrone
; ester
; estrone
; estrone glucuronide
; lactone
; river water
; sulfate
; unclassified drug
; estradiol
; estradiol-3-glucuronide
; estradiol-3-sulfate
; concentration (composition)
; degradation
; estrogenic compound
; fluvial deposit
; kinetics
; metabolite
; microbial activity
; river water
; Article
; biodegradation
; biotransformation
; degradation
; degradation kinetics
; electrospray
; mass fragmentography
; oxidation
; priority journal
; sediment
; tandem mass spectrometry
; analogs and derivatives
; bioremediation
; metabolism
; river
; sediment
; water pollutant
; Biodegradation, Environmental
; Estradiol
; Estrone
; Geologic Sediments
; Lactones
; Rivers
; Sulfates
; Water Pollutants, Chemical
英文摘要: Laboratory degradation tests with two model estrogen conjugates, 17ß-estradiol-3-glucuronide (E2-3G) and 17ß-estradiol-3-sulphate (E2-3S), using river water and sediment as inoculum under aerobic conditions were investigated. Throughout the 14-day incubation, degradation of E2-3G in river water, at environmentally-relevant level (25 ng/L), obeyed first-order kinetics with the formation of 17-ß estradiol and estrone; in contrast, E2-3S was slowly converted to estrone-3-sulphate stoichiometrically. Degradation of the two conjugates across the spiking concentrations (0.01–1 μg/g) was much faster in sediment than in river water where 25 ng/L of conjugate standards were spiked, possibly due to relatively high population densities of microorganisms in sediment. De-conjugation of the thio-ester bond at C-3 position and oxidation at C-17 position were the predominant degradation mechanisms for E2-3G and E2-3S, respectively, with negligible presence of metabolites estrone-3-glucuronide for E2-3G and 17ß-estradiol for E2-3S. In addition, delta-9(11)-dehydroestrone and 6-ketoestrone were determined as new metabolites of the two conjugates. Also, a lactone compound, hydroxylated estrone and a few sulfate conjugates were tentatively identified. With the observation of new metabolites, biodegradation pathways of E2-3G and E2-3S were proposed. The formation of new metabolites may pose unknown risks to aquatic biota. © 2018 Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112754
Appears in Collections: 气候减缓与适应
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作者单位: Department of Environmental Sciences, University of California, Riverside, CA 92521, United States; Contaminant Fate and Transport Unit, Salinity Laboratory, Agricultural Research Service, United States Department of Agriculture, Riverside, CA 92507, United States
Recommended Citation:
Ma L.,Yates S.R.. Degradation and metabolite formation of 17ß-estradiol-3-glucuronide and 17ß-estradiol-3-sulphate in river water and sediment[J]. Water Research,2018-01-01,139