globalchange  > 气候减缓与适应
DOI: 10.1016/j.watres.2018.04.008
Scopus记录号: 2-s2.0-85047430415
论文题名:
Sub-chronic inhalation of reclaimed water-induced fibrotic lesion in a mouse model
作者: Xue J.; Zhang J.; Wu Q.-Y.; Lu Y.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 139
起始页码: 240
结束页码: 251
语种: 英语
英文关键词: Fibrosis ; Inhalation ; Reclaimed water ; Sub-chronic
Scopus关键词: Aerosols ; Biological organs ; Biological water treatment ; Bioreactors ; Cell death ; Health risks ; Histology ; Irrigation ; Mammals ; Pathology ; Respiratory system ; Wastewater reclamation ; Wastewater treatment ; Adaptive immune response ; Collagen deposition ; Fibrosis ; Inhalation ; Landscape irrigation ; Potential health risks ; Re-claimed water ; Sub-chronic ; Effluents ; alpha smooth muscle actin ; collagen ; gamma interferon ; immunoglobulin A ; immunoglobulin E ; immunoglobulin G ; interleukin 10 ; interleukin 13 ; interleukin 4 ; interleukin 6 ; transforming growth factor beta1 ; tumor necrosis factor ; water ; endotoxin ; immunoglobulin ; transforming growth factor beta ; tumor necrosis factor ; apoptosis ; biomarker ; bioreactor ; cell ; immune response ; induced response ; lesion ; numerical model ; pollution exposure ; toxin ; water treatment ; adaptive immunity ; adult ; adverse outcome ; aerosol ; airway epithelium cell ; animal experiment ; animal model ; animal tissue ; apoptosis ; Article ; bronchiole ; bronchus tissue ; cell infiltration ; controlled study ; convalescence ; cytokine production ; exposure ; female ; fibrogenesis ; histopathology ; immunoglobulin blood level ; induced bronchus associated lymphoid tissue ; inflammation ; inflammatory cell ; long term exposure ; lung fibrosis ; lung injury ; lung lavage ; lung lesion ; lymphoid tissue ; main bronchus ; male ; mouse ; myofibroblast ; nonhuman ; priority journal ; sub chronic exposure ; toxic inhalation ; urban area ; waste water ; water pollutant ; water pollution ; water standard ; animal ; chemically induced ; drug effect ; immunology ; inhalational drug administration ; Institute for Cancer Research mouse ; lung ; lung fibrosis ; pathology ; recycling ; toxicity ; toxicity testing ; Administration, Inhalation ; Aerosols ; Animals ; Endotoxins ; Immunoglobulins ; Lung ; Male ; Mice, Inbred ICR ; Pulmonary Fibrosis ; Recycling ; Toxicity Tests, Subchronic ; Transforming Growth Factor beta ; Tumor Necrosis Factor-alpha ; Waste Water ; Water Pollutants
英文摘要: When reclaimed water is used as municipal miscellaneous water, acute exposure of the generated aerosol with high levels of endotoxins can cause severe inflammation in the lungs. However, the potential risks of long-term inhalation of reclaimed water remains unclear. To identify the adverse effects of sub-chronic reclaimed water inhalation and explain the underlying mechanisms, a mouse model of 12-week sub-chronic exposure was established, and wastewater before a membrane bioreactor (MBR, positive control) and the MBR effluent (reclaimed water, which met the quality standard of urban use and was currently used for landscape irrigation) were tested in this study. The exposure dose was set to approach the real working scenarios. Lung lavage and histology were analyzed. Obvious epithelial cell apoptosis in the bronchi was observed, along with the accumulation of myofibroblasts and the collagen deposition both in main bronchi and terminal bronchioles. All these symptoms were persistent after 4 weeks of recovery. Inflammation and induced bronchus-associated lymphoid tissues (iBALT) were also observed but diminished after recovery indicating inflammation may not be the direct cause of the symptom. Furthermore, two fibrogenic cytokines (TNF-α and TGF-β) were constantly high in the lung during the study. They might be the biomarkers of lung damage after the inhalation of reclaimed water. Adaptive immune responses were also detected as elevated levels of IgG and IgA, but not for IgE. Inhalation of reclaimed water causes sustained fibrotic lesions in the lungs, which suggests potential health risks during urban application where aerosols generated. © 2018 Elsevier Ltd
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112770
Appears in Collections:气候减缓与适应

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作者单位: State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing, 100084, China; Key Laboratory of Microorganism Application and Risk Control of Shenzhen, Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, China

Recommended Citation:
Xue J.,Zhang J.,Wu Q.-Y.,et al. Sub-chronic inhalation of reclaimed water-induced fibrotic lesion in a mouse model[J]. Water Research,2018-01-01,139
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