DOI: 10.1016/j.watres.2018.02.032
Scopus记录号: 2-s2.0-85042863100
论文题名: Quaternary (triphenyl-) phosphonium compounds: Environmental behavior and toxicity
作者: Brand S. ; Schlüsener M.P. ; Albrecht D. ; Kunkel U. ; Strobel C. ; Grummt T. ; Ternes T.A.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 136 起始页码: 207
结束页码: 219
语种: 英语
英文关键词: Cytotoxicity
; Genotoxicity
; LC-QTOF MS
; Partition coefficient
; Sorption
; Tetrabutylphosphonium
Scopus关键词: Catchments
; Cytotoxicity
; Liquid chromatography
; Mass spectrometry
; Phosphorus compounds
; Sorption
; Surface waters
; Time series analysis
; Elevated concentrations
; Environmental behavior
; Genotoxicities
; High resolution mass spectrometry
; LC-Q-ToF MS
; Partition coefficient
; Reactive oxygen species
; Tetrabutylphosphonium
; Suspended sediments
; phosphonium derivative
; quaternary phosphonium compound
; reactive oxygen metabolite
; surface water
; unclassified drug
; organophosphorus compound
; terphenyl derivative
; analytical method
; catchment
; chemical compound
; concentration (composition)
; environmental fate
; genotoxicity
; liquid chromatography
; mass spectrometry
; partition coefficient
; sediment analysis
; sorption
; toxicity
; Ames test
; aquatic environment
; Article
; catchment
; chemical industry
; cytotoxicity
; degradation
; ecotoxicity
; environment
; environmental factor
; genotoxicity
; liquid chromatography
; long term exposure
; mass spectrometry
; maximum concentration
; micronucleus
; micronucleus test
; oxidative phosphorylation
; priority journal
; sediment
; signal noise ratio
; suspended particulate matter
; cell survival
; chemistry
; drug effect
; environmental monitoring
; evaluation study
; Hep-G2 cell line
; high performance liquid chromatography
; human
; procedures
; river
; toxicity
; water pollutant
; Elbe River
; Rhine River
; Cell Survival
; Chromatography, High Pressure Liquid
; Environmental Monitoring
; Geologic Sediments
; Hep G2 Cells
; Humans
; Mass Spectrometry
; Organophosphorus Compounds
; Rivers
; Terphenyl Compounds
; Water Pollutants, Chemical
英文摘要: An analytical method based on high resolution mass spectrometry coupled with liquid chromatography (LC-HRMS) for 25 quaternary phosphonium compounds (QPCs) and derived phosphine oxides (POs) was developed and validated. To investigate the occurrence and fate of QPCs in the aquatic environment, water, suspended solids and sediments from the rivers Rhine and Elbe (upper and middle Elbe as well as tidal Elbe) were analyzed, as well as samples from tributaries bearing significant loads of QPCs. For the first time, the quaternary phosphonium compound tetrabutylphosphonium (Bu4P+) was detected. In the river Elbe concentrations were determined of up to 4700 ng/L (surface water) and 1000 μg/kg (sediment), respectively. Analysis of a time series of suspended solids (2005–2015) showed that QPCs have been present in the Elbe and Rhine catchment for at least one decade, with partly rising tendency. A degradation experiment with Rhine sediment revealed that triphenylphosphonium compounds (R-Ph3P+) and Bu4P+ are persistent in contact with sediment and suspended solids and tend to sorb onto sediment particles. Toxicological studies (reactive oxygen species (ROS) after substance exposure, Ames test, Micronucleus test, determination of cytotoxicity) with selected QPCs confirmed that all of them exhibit cytotoxicity and some even genotoxic potential at elevated concentrations, which emphasizes the need for an emission regulation of these compounds. © 2018 The Authors Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112859
Appears in Collections: 气候减缓与适应
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作者单位: Federal Institute of Hydrology, Department of Aquatic Chemistry, Koblenz, 56068, Germany; German Environment Agency, Section Drinking Water and Swimming Pool Water Toxicology, Bad Elster, 08645, Germany; Bavarian Environment Agency, Department of Specific Analysis for Environmental Monitoring, Augsburg, 86179, Germany
Recommended Citation:
Brand S.,Schlüsener M.P.,Albrecht D.,et al. Quaternary (triphenyl-) phosphonium compounds: Environmental behavior and toxicity[J]. Water Research,2018-01-01,136