DOI: 10.1016/j.watres.2018.01.047
Scopus记录号: 2-s2.0-85041420658
论文题名: Photodegradation of sulfasalazine and its human metabolites in water by UV and UV/peroxydisulfate processes
作者: Ji Y. ; Yang Y. ; Zhou L. ; Wang L. ; Lu J. ; Ferronato C. ; Chovelon J.-M.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 133 起始页码: 299
结束页码: 309
语种: 英语
英文关键词: Peroxydisulfate
; Photolysis
; Sulfasalazine
; Sulfate radical
; UV 254 nm
Scopus关键词: Biomolecules
; Degradation
; Health risks
; Kinetic parameters
; Kinetic theory
; Liquid chromatography
; Mass spectrometry
; Metabolites
; Phase separation
; Photolysis
; Rate constants
; Sulfur compounds
; Frontier electron densities
; Peroxydisulfate
; Pseudo first order rate constants
; Second-order rate constants
; Sulfasalazine
; Sulfate radicals
; Transformation pathways
; Triple-quadrupole mass spectrometry
; Photodegradation
; aminosalicylic acid
; bicarbonate
; hydrogen peroxide
; organic matter
; salazosulfapyridine
; sulfapyridine
; water
; mesalazine
; salazosulfapyridine
; sodium derivative
; sodium persulfate
; sulfapyridine
; sulfate
; bicarbonate
; chemical composition
; degradation
; drug
; electron density
; metabolite
; organic matter
; photodegradation
; photolysis
; radical
; sulfur dioxide
; transformation
; ultraviolet radiation
; Article
; controlled study
; density
; drug degradation
; electron
; electrophilicity
; liquid chromatography
; photodegradation
; photolysis
; priority journal
; quadrupole mass spectrometry
; rate constant
; solid phase extraction
; ultraviolet radiation
; chemistry
; human
; kinetics
; oxidation reduction reaction
; radiation response
; water management
; water pollutant
; Humans
; Hydrogen Peroxide
; Kinetics
; Mesalamine
; Oxidation-Reduction
; Photolysis
; Sodium Compounds
; Sulfapyridine
; Sulfasalazine
; Sulfates
; Ultraviolet Rays
; Water Pollutants, Chemical
; Water Purification
英文摘要: The widespread occurrence of pharmaceuticals and their metabolites in natural waters has raised great concerns about their potential risks on human health and ecological systems. This study systematically investigates the degradation of sulfasalazine (SSZ) and its two human metabolites, sulfapyridine (SPD) and 5-aminosalicylic acid (5-ASA), by UV and UV/peroxydisulfate (UV/PDS) processes. Experimental results show that SPD and 5-ASA were readily degraded upon UV 254 nm direct photolysis, with quantum yields measured to be (8.6 ± 0.8) × 10−3 and (2.4 ± 0.1) × 10−2 mol Einstein−1, respectively. Although SSZ was resistant to direct UV photolysis, it could be effectively removed by both UV/H2O2 and UV/PDS processes, with fluence-based pseudo-first-order rate constants determined to be 0.0030 and 0.0038 cm2 mJ−1, respectively. Second-order rate constant between SO4 •− and SSZ was measured as (1.33 ± 0.01) × 109 M−1s−1 by competition kinetic method. A kinetic model was established for predicting the degradation rate of SSZ in the UV/PDS process. Increasing the dosage of PDS significantly enhanced the degradation of SSZ in the UV/PDS process, which can be well predicted by the developed kinetic model. Natural water constituents, such as natural organic matter (NOM) and bicarbonate (HCO3 −), influenced the degradation of SSZ differently. The azo functional group of SSZ molecule was predicted as the reactive site susceptible to electrophilic attack by SO4 •− by frontier electron densities (FEDs) calculations. Four intermediate products arising from azo bond cleavage and SO2 extrusion were identified by solid phase extraction-liquid chromatography-triple quadrupole mass spectrometry (SPE-LC-MS/MS). Based on the products identified, detailed transformation pathways for SSZ degradation in the UV/PDS system were proposed. Results reveal that UV/PDS could be an efficient approach for remediation of water contaminated by SSZ and its metabolites. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112957
Appears in Collections: 气候减缓与适应
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作者单位: College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, 210095, China; Univ Lyon, Université Claude Bernard Lyon 1, CNRS, IRCELYON, Villeurbanne, F-69626, France
Recommended Citation:
Ji Y.,Yang Y.,Zhou L.,et al. Photodegradation of sulfasalazine and its human metabolites in water by UV and UV/peroxydisulfate processes[J]. Water Research,2018-01-01,133