DOI: 10.1016/j.watres.2017.12.071
Scopus记录号: 2-s2.0-85040234776
论文题名: Identification of the disinfection byproducts of bisphenol S and the disrupting effect on peroxisome proliferator-activated receptor gamma (PPARΓ) induced by chlorination
作者: Zheng S. ; Shi J. ; Zhang J. ; Yang Y. ; Hu J. ; Shao B.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 132 起始页码: 167
结束页码: 176
语种: 英语
英文关键词: Bisphenol S
; Chlorination
; LC-ESI-Q-ToF-MS
; PPARγ
Scopus关键词: Chlorination
; Chlorine
; Cytology
; Endocrine disrupters
; Inductively coupled plasma
; Liquid chromatography
; Mass spectrometry
; Nuclear magnetic resonance spectroscopy
; Nuclear quadrupole resonance
; Phenols
; Potable water
; Rate constants
; Water supply
; Water supply systems
; Bisphenol s
; Chlorine concentration
; Disinfection by-product
; LC-ESI-Q-ToF-MS
; Liquid chromatography-quadrupole time-of-flight mass spectrometries
; Nuclear Magnetic Resonance (NMR)
; Peroxisome proliferator-activated receptor
; Pseudo-first order reactions
; Byproducts
; bisphenol s
; chlorine
; disinfectant agent
; drinking water
; endocrine disruptor
; peroxisome proliferator activated receptor gamma
; unclassified drug
; bis(4-hydroxyphenyl)sulfone
; chlorine
; endocrine disruptor
; peroxisome proliferator activated receptor gamma
; phenol derivative
; sulfone
; activation energy
; chlorination
; concentration (composition)
; disinfection
; drinking water
; endocrine disruptor
; experimental study
; identification method
; induced response
; metabolism
; phenolic compound
; reaction rate
; Article
; carbon nuclear magnetic resonance
; chlorination
; controlled study
; disinfection
; liquid chromatography-mass spectrometry
; pH
; priority journal
; proton nuclear magnetic resonance
; purification
; quadrupole mass spectrometry
; rate constant
; reaction analysis
; simulation
; time of flight mass spectrometry
; water supply
; chemistry
; disinfection
; halogenation
; HEK293 cell line
; human
; liquid chromatography
; metabolism
; pharmacology
; tandem mass spectrometry
; water pollutant
; Chlorine
; Chromatography, Liquid
; Disinfection
; Drinking Water
; Endocrine Disruptors
; Halogenation
; HEK293 Cells
; Humans
; Phenols
; PPAR gamma
; Sulfones
; Tandem Mass Spectrometry
; Water Pollutants, Chemical
英文摘要: Bisphenol S (BPS), an alternative product to bisphenol A (BPA), has been the focus of increasing public concern due to its potential endocrine disrupting effect and its adverse effects related to metabolic disorders such as obesity. The detection of its residue in drinking water supply systems suggests that BPS can be chlorinated; however, whether its endocrine disrupting effect can be disrupted by this chlorination remains unclear. In the present study, we identified the byproducts of the reaction of BPS with chlorine and assessed the effect of the main byproducts on peroxisome proliferator-activated receptor gamma (PPARγ). BPS was chlorinated in a simulation experiment. The chlorination reaction in this study was chlorine and pH dependent, and the pseudo-first-order reaction rate constant was controlled by the chlorine concentration and pH. The reaction rate at pH 8.5 was 7 times faster than that at pH 6.5. Twenty-two byproducts were putatively identified by liquid chromatography quadrupole time-of-flight mass spectrometry (LC-ESI-Q-ToF-MS), and five main byproducts were purified and characterized by 1H and 13C nuclear magnetic resonance (NMR) spectroscopy. The PPARγ effects of the byproducts were assayed, revealing a2-to4-fold enhancement in their activities in comparison with the parent compound. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112970
Appears in Collections: 气候减缓与适应
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作者单位: Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, 100193, China; Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control100013, China; College of Urban and Environment Sciences, Peking University, Beijing, 100871, China; College of Public Health, Capital Medical University, Beijing, 100069, China
Recommended Citation:
Zheng S.,Shi J.,Zhang J.,et al. Identification of the disinfection byproducts of bisphenol S and the disrupting effect on peroxisome proliferator-activated receptor gamma (PPARΓ) induced by chlorination[J]. Water Research,2018-01-01,132