globalchange  > 气候减缓与适应
DOI: 10.1016/j.watres.2017.12.077
Scopus记录号: 2-s2.0-85041662799
论文题名:
A tiered approach to assess effects of diclofenac on the brown mussel Perna perna: A contribution to characterize the hazard
作者: Fontes M.K.; Gusso-Choueri P.K.; Maranho L.A.; Abessa D.M.D.S.; Mazur W.A.; de Campos B.G.; Guimarães L.L.; de Toledo M.S.; Lebre D.; Marques J.R.; Felicio A.A.; Cesar A.; Almeida E.A.; Pereira C.D.S.
刊名: Water Research
ISSN: 431354
出版年: 2018
卷: 132
起始页码: 361
结束页码: 370
语种: 英语
英文关键词: Marine environment ; Non-target organism ; Nonsteroidal anti-inflammatory drug ; Pharmaceuticals
Scopus关键词: Coastal zones ; Discharge (fluid mechanics) ; Drug products ; Ecology ; Ecosystems ; Environmental regulations ; Hazards ; Laws and legislation ; Marine biology ; Molluscs ; Sewage treatment plants ; Wastewater disposal ; Wastewater treatment ; Environmental concentration ; Environmental concerns ; Environmental hazards ; Environmental legislations ; Lysosomal membrane stabilities ; Marine environment ; Non-steroidal anti-inflammatory drugs ; Non-target organism ; Aquatic ecosystems ; diclofenac ; sea water ; aquatic ecosystem ; assessment method ; chemical pollutant ; concentration (composition) ; crustacean ; drug ; marine ecosystem ; marine environment ; nontarget organism ; pollution effect ; sewage treatment ; waste disposal ; Article ; coastal waters ; DNA damage ; embryo development ; fertilization ; lysosome membrane ; nonhuman ; oxidative stress ; Perna perna ; priority journal ; Perna perna
英文摘要: Pharmaceutical discharges into the aquatic ecosystem are of environmental concern and sewage treatment plants (STPs) have been pointed out as the major source of these compounds to coastal zones, where oceanic disposal of sewage occurs through submarine outfalls. Diclofenac (DCF) is one of the most frequently detected pharmaceuticals in water, but little is known about the effects on marine organisms. In this study, we employed a tiered approach involving the determination of environmental concentrations of DCF in marine water and the adverse biological effects for fertilization, embryo-larval development and biomarker responses of the mussel Perna perna. Results indicate that effects in fertilization rate and embryo-larval development were found in the order of mg·L−1. However, low concentrations of DCF (ng·L−1) significantly decreased the lysosomal membrane stability and COX activity, as well as triggered DNA damage, oxidative stress and changes in antioxidant defenses. Our results point to an environmental hazard at coastal ecosystems and suggest the need for improvements in the treatment of domestic wastewater aiming to reduce DCF concentrations, as well as regulation on current environmental legislation and monitoring of aquatic ecosystems. © 2017 Elsevier Ltd
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/112977
Appears in Collections:气候减缓与适应

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作者单位: Departamento de Ciências do Mar, Universidade Federal de São Paulo, Rua Maria Máximo, 168, Santos, 11030-100, Brazil; Instituto de Biociências, Campus do Litoral Paulista, Universidade Estadual Paulista “Júlio de Mesquita Filho”, Infante Dom Henrique, s/n, São Vicente, 11330-900, Brazil; Laboratório de Ecotoxicologia, Universidade Santa Cecília, Rua Oswaldo Cruz 266, Santos, 11045-907, Brazil; Departamento de Bioquímica da Universidade Federal de São Paulo, Rua Botucatu, 862, São Paulo, 04023-901, Brazil; CEMSA – Centro de Espectrometria de Massas Aplicada, CIETEC/IPEN, Av. Prof. Lineu Prestes, 2242, Salas 112 e 113, São Paulo, 05508-000, Brazil; Universidade Estadual Paulista Júlio de Mesquita Filho – Campus São José do Rio Preto, Rua Cristóvão Colombo 2265, São José do Rio Preto, SP 15054-000, Brazil; Fundação Universidade Regional de Blumenau, Rua Antônio da Veiga 498, Itoupava Seca, Blumenau, 89030-103, Brazil

Recommended Citation:
Fontes M.K.,Gusso-Choueri P.K.,Maranho L.A.,et al. A tiered approach to assess effects of diclofenac on the brown mussel Perna perna: A contribution to characterize the hazard[J]. Water Research,2018-01-01,132
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