globalchange  > 气候变化事实与影响
DOI: 10.1289/EHP277
论文题名:
Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability
作者: Kristen Lyall; 1* Lisa. A. Croen; 2; reas Sjödin; 3 Cathleen K. Yoshida; 2 Ousseny Zerbo; 2 Martin Kharrazi; 1; Gayle C. Windham1
刊名: Environmental Health Perspectives
ISSN: 0091-6834
出版年: 2017
卷: Volume 125, 期:Issue 3
起始页码: 474
语种: 英语
英文摘要: Background: Polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are neurodevelopmental toxicants, but few studies have examined associations with autism spectrum disorder (ASD).

Objectives: We aimed to determine whether prenatal exposure to PCBs and OCPs influences offspring risk of ASD and intellectual disability without autism (ID).

Methods: We conducted a population-based case–control study among Southern California births, including children with ASD (n = 545) meeting Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV-TR) criteria and ID (n = 181), as well as general population (GP) controls (n = 418). Concentrations of 11 PCB congeners and 2 OCPs measured in banked second-trimester serum samples were compared between the diagnostic groups. Logistic regression was used to calculate crude and adjusted odds ratios (AOR) for associations with ASD, and separately for ID, compared with GP controls, by quartiles of analyte concentrations in primary analyses.

Results: Geometric mean levels of several PCB congeners were higher in the ASD group than in the ID and GP groups. ASD risk was elevated for a number of PCB congeners, particularly for the highest vs. lowest quartile of PCB138/158 (AOR = 1.79; 95% CI: 1.10, 2.71) and PCB153 (AOR = 1.82; 95% CI: 1.10, 3.02), and for highest deciles of other congeners in secondary analyses. PCB138/158 was also associated with increased ID (AOR = 2.41; 95% CI: 1.18, 4.91), though no trend was suggested. OCPs were not associated with increased risk of ASD in primary analyses, whereas nonmonotonic increases in risk of ID were found with p,p´-DDE.

Conclusions: Our results suggest higher levels of some organochlorine compounds during pregnancy are associated with ASD and ID.
URL: http://dx.doi.org/10.1289/EHP277
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12165
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: 1Environmental Health Investigations Branch, California Department of Public Health, Richmond, California, USA; 2Division of Research, Kaiser Permanente, Oakland, California, USA; 3Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Recommended Citation:
Kristen Lyall,1* Lisa. A. Croen,2,et al. Polychlorinated Biphenyl and Organochlorine Pesticide Concentrations in Maternal Mid-Pregnancy Serum Samples: Association with Autism Spectrum Disorder and Intellectual Disability[J]. Environmental Health Perspectives,2017-01-01,Volume 125(Issue 3):474
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