DOI: 10.1016/j.watres.2018.12.048
Scopus记录号: 2-s2.0-85059804190
论文题名: Cyanobacterial peptides beyond microcystins – A review on co-occurrence, toxicity, and challenges for risk assessment
作者: Janssen E.M.-L.
刊名: Water Research
ISSN: 431354
出版年: 2019
起始页码: 488
结束页码: 499
语种: 英语
英文关键词: Cyanobacteria
; Ecotoxicology
; Harmful algal bloom
; Human health
; Risk assessment
; Toxin
Scopus关键词: Ecology
; Health risks
; Metabolites
; Risk management
; Toxicity
; Water quality
; Cyanobacteria
; Eco-toxicology
; Harmful algal blooms
; Human health
; Toxin
; Risk assessment
; bacterial toxin
; cyanopeptide
; fresh water
; microcystin
; phosphoprotein phosphatase
; unclassified drug
; algal bloom
; concentration (composition)
; cyanobacterium
; disease prevalence
; ecotoxicology
; enzyme
; enzyme activity
; metabolite
; peptide
; public health
; risk assessment
; toxicity
; toxin
; water quality
; algal bloom
; biological activity
; cyanobacterium
; ecosystem health
; ecotoxicology
; enzyme inhibition
; exposure
; grazer
; human
; natural resource
; nonhuman
; peptide analysis
; priority journal
; Review
; risk assessment
; toxicity
; water treatment
; algae
; Cyanobacteria
英文摘要: Cyanobacterial bloom events that produce natural toxins occur in freshwaters across the globe, yet the potential risk of many cyanobacterial metabolites remains mostly unknown. Only microcystins, one class of cyanopeptides, have been studied intensively and the wealth of evidence regarding exposure concentrations and toxicity led to their inclusion in risk management frameworks for water quality. However, cyanobacteria produce an incredible diversity of hundreds of cyanopeptides beyond the class of microcystins. The question arises, whether the other cyanopeptides are in fact of no human and ecological concern or whether these compounds merely received (too) little attention thus far. Current observations suggest that an assessment of their (eco)toxicological risk is indeed relevant: First, other cyanopeptides, including cyanopeptolins and anabaenopeptins, can occur just as frequently and at similar nanomolar concentrations as microcystins in surface waters. Second, cyanopeptolins, anabaenopeptins, aeruginosins and microginins inhibit proteases in the nanomolar range, in contrast to protein phosphatase inhibition by microcystins. Cyanopeptolins, aeruginosins, and aerucyclamide also show toxicity against grazers in the micromolar range comparable to microcystins. The key challenge for a comprehensive risk assessment of cyanopeptides remains their large structural diversity, lack of reference standards, and high analytical requirements for identification and quantification. One way forward would be a prevalence study to identify the priority candidates of tentatively abundant, persistent, and toxic cyanopeptides to make comprehensive risk assessments more manageable. © 2019 The Author(s) Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/122033
Appears in Collections: 气候变化事实与影响
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作者单位: Swiss Federal Institute of Aquatic Science and Technology, Eawag, Dübendorf, 8600, Switzerland
Recommended Citation:
Janssen E.M.-L.. Cyanobacterial peptides beyond microcystins – A review on co-occurrence, toxicity, and challenges for risk assessment[J]. Water Research,2019-01-01