DOI: 10.1016/j.watres.2018.10.057
Scopus记录号: 2-s2.0-85055908246
论文题名: The DBP exposome: Development of a new method to simultaneously quantify priority disinfection by-products and comprehensively identify unknowns
作者: Kimura S.Y. ; Cuthbertson A.A. ; Byer J.D. ; Richardson S.D.
刊名: Water Research
ISSN: 431354
出版年: 2019
起始页码: 324
结束页码: 333
语种: 英语
英文关键词: DBPs
; Disinfection by-products
; Drinking water
; Non-target analysis
; Quantification
Scopus关键词: Disinfection
; Fumigation
; Gas chromatography
; Mass spectrometers
; Mass spectrometry
; Water analysis
; Water pollution
; DBPs
; Disinfection by-product
; Iodinated trihalomethanes
; Non-target analysis
; Quantification
; Selected ion monitoring
; Single-quadrupole mass spectrometers
; Time-of-flight mass spectrometers
; Potable water
; bromide
; dibutylnitrosamine
; disinfectant agent
; drinking water
; haloacetaldehyde
; haloacetamide
; haloacetonitrile
; haloketone
; halonitromethane
; iodide
; iodinated trihalomethane
; n,n dimethylacetamide
; organic matter
; unclassified drug
; byproduct
; chemical compound
; detection method
; disinfection
; drinking water
; instrumentation
; numerical method
; organic matter
; quantitative analysis
; Article
; calibration
; chemical waste
; disinfection by product
; health hazard
; limit of detection
; mass fragmentography
; priority journal
; time of flight mass spectrometry
; water management
; water sampling
英文摘要: Disinfected drinking water contains hundreds of disinfection by-products (DBPs) that are formed by the reaction of disinfectants with natural and anthropogenic organic matter, bromide, and iodide. Understanding what these DBPs are is important because millions of people worldwide consume drinking water every day, and human epidemiologic studies have reported cancer, miscarriage, and birth defects from consuming such waters. While more than 600 DBPs are reported in the literature, very few studies quantify complete classes of chlorinated, brominated, and iodinated DBPs. Also, very few studies conduct comprehensive non-target analyses of unknown DBPs to characterize the complete DBP exposure (the exposome). We developed a new gas chromatography (GC)-mass spectrometry (MS) method that simultaneously quantifies 39 priority unregulated DBPs from six different chemical classes (haloacetaldehydes, haloketones, haloacetamides, haloacetonitriles, halonitromethanes, and iodinated-trihalomethanes) and analyzes unknown DBPs with mass accuracy <600 ppm under full-scan conditions. Using a new type of time-of-flight (TOF) mass spectrometer, which combines selected ion monitoring (SIM)-level sensitivity with mass accuracy of ±0.05 Da, method detection limits of 3–61 ng/L were achieved. These levels were found to be quite comparable to those of a widely used single quadrupole mass spectrometer (2–90 ng/L) operated in SIM mode. However, analysis using this TOF mass spectrometer offers two additional advantages over traditional quadrupole-MS: (1) full-scan data, which provides additional confidence for target analytes, as well as complete mass spectra for unknown analysis, and (2) two decimal place mass accuracy, which allows additional confidence for target analytes and importantly, molecular formula indication for unknowns. High resolution accurate mass TOF was also used to validate identification of selected compounds. This new method was demonstrated on finished drinking waters from three different drinking water plants, where target quantification and non-target unknown analyses were performed simultaneously during the same run. This enabled the quantification of 39 DBPs, along with the non-target identification of many other drinking water contaminants, including two additional non-target DBPs: N,N-dimethylacetamide and N-nitrosodibutylamine. © 2018 The Authors Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/122195
Appears in Collections: 气候变化事实与影响
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作者单位: Department of Chemistry and Biochemistry, University of South Carolina, Columbia, SC 29208, United States; Department of Chemistry, University of Calgary, Calgary, Alberta T2N 1N4, Canada; LECO Corp., 3000 Lakeview Ave., St. Joseph, Michigan, 49085, United States
Recommended Citation:
Kimura S.Y.,Cuthbertson A.A.,Byer J.D.,et al. The DBP exposome: Development of a new method to simultaneously quantify priority disinfection by-products and comprehensively identify unknowns[J]. Water Research,2019-01-01