DOI: 10.1016/j.watres.2018.10.027
Scopus记录号: 2-s2.0-85055017917
论文题名: Influence of chemical speciation on photochemical transformation of three fluoroquinolones (FQs) in water: Kinetics, mechanism, and toxicity of photolysis products
作者: Zhang Z. ; Xie X. ; Yu Z. ; Cheng H.
刊名: Water Research
ISSN: 431354
出版年: 2019
卷: 148 起始页码: 19
结束页码: 29
语种: 英语
英文关键词: Chemical speciation
; Degradation pathway
; Direct photolysis
; Fluoroquinolone
; Indirect photolysis
; Self-sensitized photolysis
Scopus关键词: Carboxylation
; Degradation
; Drug products
; Kinetics
; Photodegradation
; Photolysis
; Toxicity
; Bioluminescence inhibitions
; Degradation pathways
; Direct photolysis
; Electron-donating group
; Fluoroquinolones
; Fluoroquinolones (FQs)
; Photochemical transformations
; Photodegradation pathway
; Chemical speciation
; ampholyte
; hydroxyl radical
; lomefloxacin
; norfloxacin
; ofloxacin
; quinolone derivative
; water
; chemical compound
; chemical method
; dehydroxylation
; numerical model
; photochemistry
; photodegradation
; photolysis
; reaction kinetics
; speciation (chemistry)
; toxicity
; transformation
; water treatment
; Aliivibrio fischeri
; Article
; bioluminescence
; chemical structure
; controlled study
; decarboxylation
; defluorination
; kinetics
; nonhuman
; oxidation
; photochemistry
; photodegradation
; photolysis
; quantum yield
; toxicity
; Vibrio fischeri
英文摘要: This study investigated the contribution of direct, indirect, and self-sensitized photolysis to the photochemical fate of three model fluoroquinolones (FQs), i.e., lomefloxacin (LOM), norfloxacin (NOR), and ofloxacin (OFL), and demonstrated the influence of chemical speciation on their photodegradation behavior, a topic that has received relatively little attention. Results suggest that these FQs in water transformed mainly via direct photolysis, while hydroxyl radical played a key role in their indirect and self-sensitized photolysis. Chemical speciation of such zwitterionic compounds significantly affected the kinetics of their phototransformation, with the quantum yields of photodegradation decreased in the order of zwitterionic (FQsH) > anionic (FQs − ) > cationic (FQsH 2 + ). The photodegradation pathways of FQs depended on both their structures and chemical speciation. Defluorination for LOM in C-8 and NOR in C-6 was more significant when they were present in zwitterionic form than in the other forms. Cationic FQs underwent direct piperazinyl ring cleavage, and zwitterionic ones underwent piperazinyl ring oxidation, while the degradation pathway of piperazinyl ring for FQs in anionic form was structure dependent. Decarboxylation for zwitterionic FQs occurred more slowly compared to both cationic and anionic ones, and the FQs bearing electron-donating groups in C-8 position degraded more easily in cationic form than the anionic ones, while the opposite was true for the FQs without such a group in C-8 position. Results of Vibrio fischeri bioluminescence inhibition tests showed the toxicity of zwitterionic NOR and OFL significantly decreased after photodegradation, while the degradation products of LOM exhibited greater toxicity. These findings indicate that chemical speciation of zwitterionic compounds could affect the kinetics and pathways of their photochemical transformation, and thus have important implications on their fate and risk in aquatic environment. © 2018 Elsevier Ltd Citation statistics:
资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/122232
Appears in Collections: 气候变化事实与影响
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作者单位: State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, 510640, China; MOE Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China
Recommended Citation:
Zhang Z.,Xie X.,Yu Z.,et al. Influence of chemical speciation on photochemical transformation of three fluoroquinolones (FQs) in water: Kinetics, mechanism, and toxicity of photolysis products[J]. Water Research,2019-01-01,148