DOUBLE-STRAND BREAKS
; CHROMOSOME DYNAMICS
; MOTION
; CHECKPOINT
; RAD9
; REVEALS
; SITE
; KU
; ORGANIZATION
; MOVEMENT
WOS学科分类:
Genetics & Heredity
WOS研究方向:
Genetics & Heredity
英文摘要:
Chromosome organization and chromatin mobility are central to DNA metabolism. In particular, it has been recently shown by several labs that double strand breaks (DSBs) in yeast induce a change in chromatin mobility at the site of the damage. Intriguingly, DSB also induces a global mobility of the genome, at others, potentially undamaged positions. How mobility is regulated and what are the functional outcomes of these global changes in chromatin dynamics are, however, not yet fully understood. We present the current state of knowledge in light of the recent literature and discuss some perspectives opened by these discoveries towards genome stability.
1.Inst Pasteur, Unite Imagerie & Modelisat, 25 Rue Docteur Roux, F-75015 Paris, France 2.CNRS, UMR 3691, Paris, France 3.CNRS, IP, C3BI, USR 3756, Paris, France 4.Hop St Louis, Inst Univ Hematol, Equipe Biol & Dynam Chromosomes, Paris, France 5.Univ Paris Diderot, Sorbonne Paris Cite, IUH, INSERM,U944,CNRS,UMR 7212, Paris, France
Recommended Citation:
Zimmer, Christophe,Fabre, Emmanuelle. Chromatin mobility upon DNA damage: state of the art and remaining questions[J]. CURRENT GENETICS,2019-01-01,65(1):1-9