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An innovative approach of using agro-ecological zones (AEZs), instead of using political boundaries, has been adopted for climate change impact analysis on rice production of India. The analysis has been carried out by using a process-based Crop Simulation Model (CSM)-CERES-Rice fed with improved state of art bias corrected climate projections from eight Global Climate Models (GCMs) for four expected climatic scenarios Representative Concentration Pathways (RCP 2.6, 4.5, 6.0 and 8.5). Using weather-soil-crop information along with year-wise effect of CO2 increase assumption for different RCPs as input to the crop model, simulations were performed for the base period (1976-2005) as well as three future periods (2020s: 2006-2035, 2050s: 2036-2065, and 2080s: 2066-2095) for insight understanding of climate change impact on rice yield. Model simulated rice yields of future periods were compared with that of the base period to quantify the climate change impact. Results based on multi-GCM ensemble show expected increase in rice yield of most of the AEZs in RCP 2.6 but as on moving towards RCP 8.5 through RCP 4.5 and 6.0, the positive impact on rice yield in RCP 2.6, in major rice producing zones, is expected to mitigate and lead to the negative impact by 2080s. Large spatio-temporal variability is expected in most of the zones with humongous variability in arid and hilly zones. The overall change in spatial rice yield in India taking all used GCM-RCP combinations in consideration is expected to vary from 1.2 to 8.8%, 0.7 to 12.6% and -2.9 to 17.8% due to the expected climate change in 2020s, 2050s and 2080s, respectively.