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In sub-Saharan Africa, livestock is one of the key channels through which most households meet their food security needs. However, diseases such as the African Animal Trypanosomosis (AAT) constrain productivity. Using data from 445 randomly sampled small-scale cattle farmers, this paper investigates the role of integrated livestock disease control on household food security. Using a novel approach to link different food security measures to cattle productivity, the paper identifies the channels of impact at the household level. Methodologically, the paper estimated the propensity score matching algorithm to net out the effect of adoption. The results show that households who adopt RDU have record livestock productivity and higher consumption per capita expenditures. They tend to be more food secure, experience lower seasonal food supply fluctuations and experience a lower probability of falling below the food poverty line.