globalchange  > 气候变化事实与影响
DOI: 10.1289/ehp.1408564
论文题名:
Evaluating Health Risks from Inhaled Polychlorinated Biphenyls: Research Needs for Addressing Uncertainty
作者: Geniece M. Lehmann; 1 Krista Christensen; 2 Mark Maddaloni; 3; Linda J. Phillips2
刊名: Environmental Health Perspectives
ISSN: 0091-7148
出版年: 2015
卷: Volume 123, 期:Issue 2
起始页码: 109
语种: 英语
英文摘要: Background: Indoor air concentrations of polychlorinated biphenyls (PCBs) in some buildings are one or more orders of magnitude higher than background levels. In response to this, efforts have been made to assess the potential health risk posed by inhaled PCBs. These efforts are hindered by uncertainties related to the characterization and assessment of source, exposure, and exposure-response.

Objectives: We briefly describe some common sources of PCBs in indoor air and estimate the contribution of inhalation exposure to total PCB exposure for select age groups. Next, we identify critical areas of research needed to improve assessment of exposure and exposure response for inhaled PCBs.

Discussion: Although the manufacture of PCBs was banned in the United States in 1979, many buildings constructed before then still contain potential sources of indoor air PCB contamination. In some indoor settings and for some age groups, inhalation may contribute more to total PCB exposure than any other route of exposure. PCB exposure has been associated with human health effects, but data specific to the inhalation route are scarce. To support exposure–response assessment, it is critical that future investigations of the health impacts of PCB inhalation carefully consider certain aspects of study design, including characterization of the PCB mixture present.

Conclusions: In certain contexts, inhalation exposure to PCBs may contribute more to total PCB exposure than previously assumed. New epidemiological and toxicological studies addressing the potential health impacts of inhaled PCBs may be useful for quantifying exposure–response relationships and evaluating risks.
URL: https://ehp.niehs.nih.gov/1408564
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12479
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: 1National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; 2National Center for Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, USA; 3Region 2, U.S. Environmental Protection Agency, New York, New York, USA

Recommended Citation:
Geniece M. Lehmann,1 Krista Christensen,2 Mark Maddaloni,et al. Evaluating Health Risks from Inhaled Polychlorinated Biphenyls: Research Needs for Addressing Uncertainty[J]. Environmental Health Perspectives,2015-01-01,Volume 123(Issue 2):109
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