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Global environmental changes, driven by the consequences of human activities and population growth, are altering our planet in ways that pose current threats to human health, with the magnitude of these threats projected to increase over coming decades if additional, proactive actions are not taken. Global changes, unprecedented in their geospatial and temporal scales, include climate change, marine pollution, ozone layer depletion, soil degradation, and urbanization. Climate change is the best studied. The health risks of a changing climate will become increasingly urgent as climate change affects the quantity and quality of food and water, increases air pollution, alters the distribution of vectors/pathogens and disease transmission dynamics, and reduces eco-physical buffering against extreme weather and climate events. Health systems urgently need to be improved to effectively address these emerging challenges. This paper provides an overview of the health consequences of climate change, and discusses how health risks can be minimized and avoided via mitigation and adaptation pathways.