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Injury of honeybees with climate change will jeopardise pollination and food security. Thermodynamic parameters which may affect the honeybees due to global warming are assessed based on their sucrose metabolism. With 3,000 honeybees, work performance was 3.17 kJ/kg dry air, heat generation was 4.44 kJ/kg dry air and the entropy generation is 161.6 W/g honeybee K while raising the temperature of the hive by 1 degrees C. On the other hand, they have to perform 4.5 kJ/kg dry air of work, generate 7.27 kJ/kg dry air of heat and 308.9 W/g honeybee K of entropy to reduce the temperature of the hive by 1 degrees C. The results show that during cooling by 1 degrees C the honeybees perform 1.4 folds of work and generate 1.9 folds of entropy when compared to that of heating by 1 degrees C, implying that global warming may create 90% more entropy stress on the honeybees, when compared to that of cooling.