全球变化知识资源中心

Asthmatic patients often suffer from bronchoconstriction or asthma following breathing hot air or exposure to exercise due to raises the core body temperature. However, the direct effect of heating airways has not been studied yet. The aim of this study is to investigate the effect of heating on tracheal and bronchiolar smooth muscles. Isolated ovine tracheal strips and bronchiolar segments preparations were suspended in organ baths containing Krebs' solution for isometric tension recording. Tissues responses were examined during decreasing and elevating baths temperature (20 degrees C, 40 degrees C-45 degrees C and 50 degrees C). Cooling or heating induced rapid and reproducible contractions proportional with decreasing or increasing temperature respectively in tracheal and bronchiolar preparations. On reset to 37 degrees C the tone returned rapidly to basal level. Changing the bath's temperature from 37 degrees C to 20 degrees C or to 40 degrees C and 45 degrees C for tracheal strips or to 45 degrees C and 50 degrees C for bronchiolar segments induced contractions in both preparations. Changing the temperature below or above the normal body temperature (37 degrees C), leads to airways contractions. Heating induced contractions in tracheal and bronchiolar smooth muscle proportional to the heating temperature. Therefore, breathing hot air or elevation of body core temperature due to exercise can be considered possible causative factor of heating- or exercise-induced bronchoconstriction.