globalchange  > 气候变化事实与影响
DOI: 10.1289/ehp.1409342
论文题名:
Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making
作者: Elisabet Berggren; 1 Patric Amcoff; 2 Romualdo Benigni; 3 Karen Blackburn; 4 Edward Carney; 5 Mark Cronin; 6 Hubert Deluyker; 7 Francoise Gautier; 8 Richard S. Judson; 9 Georges E.N. Kass; 7 Detlef Keller; 10 Derek Knight; 11 Werner Lilienblum; 12 Catherine Mahony; 13 Ivan Rusyn; 14 Terry Schultz; 15 Michael Schwarz; 16 Gerrit Schüürmann; 17; 18; rew White; 19 Julien Burton; 1 Alfonso M. Lostia; 1 Sharon Munn; 1; rew Worth1
刊名: Environmental Health Perspectives
ISSN: 0091-7332
出版年: 2015
卷: Volume 123, 期:Issue 12
起始页码: 1232
语种: 英语
英文摘要: Background: Safety assessment for repeated dose toxicity is one of the largest challenges in the process to replace animal testing. This is also one of the proof of concept ambitions of SEURAT-1, the largest ever European Union research initiative on alternative testing, co-funded by the European Commission and Cosmetics Europe. This review is based on the discussion and outcome of a workshop organized on initiative of the SEURAT-1 consortium joined by a group of international experts with complementary knowledge to further develop traditional read-across and include new approach data.

Objectives: The aim of the suggested strategy for chemical read-across is to show how a traditional read-across based on structural similarities between source and target substance can be strengthened with additional evidence from new approach data—for example, information from in vitro molecular screening, “-omics” assays and computational models—to reach regulatory acceptance.

Methods: We identified four read-across scenarios that cover typical human health assessment situations. For each such decision context, we suggested several chemical groups as examples to prove when read-across between group members is possible, considering both chemical and biological similarities.

Conclusions: We agreed to carry out the complete read-across exercise for at least one chemical category per read-across scenario in the context of SEURAT-1, and the results of this exercise will be completed and presented by the end of the research initiative in December 2015.
URL: https://ehp.niehs.nih.gov/1409342
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12661
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: 1Joint Research Centre, European Commission, Ispra, Italy; 2Cosmetics Europe, Brussels, Belgium; 3OECD (Organisation for Economic Co-operation and Development), Paris, France; 4Procter & Gamble, Cincinnati, Ohio, USA; 5The Dow Chemical Company, Midland, Michigan, USA; 6Liverpool John Moores University, Liverpool, United Kingdom; 7EFSA (European Food Safety Authority), Parma, Italy; 8L’Oréal, Asnières-sur-Seine, France; 9U.S. Environmental Protection Agency, Washington, DC, USA; 10Henkel AG & Co, Düsseldorf, Germany; 11ECHA (European Chemicals Agency), Helsinki, Finland; 12SCCS (Scientific Committee on Consumer Safety), Luxembourg; 13Procter & Gamble, Egham, UK; 14Texas A&M University, College Station, Texas, USA; 15The University of Tennessee, Knoxville, Tennessee, USA; 16Tübingen University, Tübingen, Germany; 17Helmholtz Centre for Environmental Research, Leipzig, Germany; 18Institute for Organic Chemistry, Technical University Bergakademie Freiberg, Freiberg, Germany; 19Unilever PLC, Milton Keynes, United Kingdom

Recommended Citation:
Elisabet Berggren,1 Patric Amcoff,2 Romualdo Benigni,et al. Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making[J]. Environmental Health Perspectives,2015-01-01,Volume 123(Issue 12):1232
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