globalchange  > 气候变化事实与影响
DOI: 10.1289/ehp.1409251
论文题名:
Acrolein Exposure in U.S. Tobacco Smokers and Non-Tobacco Users: NHANES 2005–2006
作者: K. Udeni Alwis; B. Rey deCastro; John C. Morrow; Benjamin C. Blount
刊名: Environmental Health Perspectives
ISSN: 0091-7340
出版年: 2015
卷: Volume 123, 期:Issue 12
起始页码: 1302
语种: 英语
英文摘要: Background: Acrolein is a highly reactive α,β unsaturated aldehyde and respiratory irritant. Acrolein is formed during combustion (e.g., burning tobacco or biomass), during high-temperature cooking of foods, and in vivo as a product of oxidative stress and polyamine metabolism. No biomonitoring reference data have been reported to characterize acrolein exposure for the U.S. population.

Objectives: Our goals were to a) evaluate two acrolein metabolites in urine—N-acetyl-S-(3-hydroxypropyl)-L-cysteine (3HPMA) and N-acetyl-S-(2-carboxyethyl)-L-cysteine (CEMA)—as biomarkers of exposure to acrolein for the U.S. population by age, sex, race, and smoking status; and b) assess tobacco smoke as a predictor of acrolein exposure.

Methods: We analyzed urine from National Health and Nutrition Examination Survey (NHANES 2005–2006) participants ≥ 12 years old (n = 2,866) for 3HPMA and CEMA using ultra-high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UPLC/ESI-MSMS). Sample-weighted linear regression models stratified for non-tobacco users versus tobacco smokers (as defined by serum cotinine and self-report) characterized the association of urinary 3HPMA and CEMA with tobacco smoke exposure, adjusting for urinary creatinine, sex, age, and race/ethnicity.

Results: 3HPMA and CEMA levels were higher among tobacco smokers (cigarettes, cigars, and pipe users) than among non-tobacco users. The median 3HPMA levels for tobacco smokers and non-tobacco users were 1,089 and 219 μg/g creatinine, respectively. Similarly, median CEMA levels were 203 μg/g creatinine for tobacco smokers and 78.8 μg/g creatinine for non-tobacco users. Regression analysis showed that serum cotinine was a significant positive predictor (p < 0.0001) of both 3HPMA and CEMA among tobacco smokers.

Conclusions: Tobacco smoke was a significant predictor of acrolein exposure in the U.S. population.
URL: https://ehp.niehs.nih.gov/1409251
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12669
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA

Recommended Citation:
K. Udeni Alwis,B. Rey deCastro,John C. Morrow,et al. Acrolein Exposure in U.S. Tobacco Smokers and Non-Tobacco Users: NHANES 2005–2006[J]. Environmental Health Perspectives,2015-01-01,Volume 123(Issue 12):1302
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