globalchange  > 气候变化事实与影响
DOI: 10.1289/ehp.1307187
论文题名:
Maternal Blood, Plasma, and Breast Milk Lead: Lactational Transfer and Contribution to Infant Exposure
作者: Adrienne S. Ettinger; 1; 2 Ananya Roy; 1 Chitra J. Amarasiriwardena; 2; 3 Donald Smith; 4 Nicola Lupoli; 2; 3 Adriana Mercado-García; 5 Hector Lamadrid-Figueroa; 5 Martha Maria Tellez-Rojo; 5 Howard Hu; 6; Mauricio Hernández-Avila7
刊名: Environmental Health Perspectives
ISSN: 0091-7360
出版年: 2014
卷: Volume 122, 期:Issue 1
起始页码: 87
语种: 英语
英文摘要: Background: Human milk is a potential source of lead exposure. Yet lactational transfer of lead from maternal blood into breast milk and its contribution to infant lead burden remains poorly understood.

Objectives: We explored the dose–response relationships between maternal blood, plasma, and breast milk to better understand lactational transfer of lead from blood and plasma into milk and, ultimately, to the breastfeeding infant.

Methods: We measured lead in 81 maternal blood, plasma, and breast milk samples at 1 month postpartum and in 60 infant blood samples at 3 months of age. Milk-to-plasma (M/P) lead ratios were calculated. Multivariate linear, piecewise, and generalized additive models were used to examine dose–response relationships between blood, plasma, and milk lead levels.

Results: Maternal lead levels (mean ± SD) were as follows: blood: 7.7 ± 4.0 μg/dL; plasma: 0.1 ± 0.1 μg/L; milk: 0.8 ± 0.7 μg/L. The average M/P lead ratio was 7.7 (range, 0.6–39.8) with 97% of the ratios being > 1. The dose–response relationship between plasma lead and M/P ratio was nonlinear (empirical distribution function = 6.5, p = 0.0006) with the M/P ratio decreasing by 16.6 and 0.6 per 0.1 μg/L of plasma lead, respectively, below and above 0.1 μg/L plasma lead. Infant blood lead level (3.4 ± 2.2 μg/dL) increased by 1.8 μg/dL per 1 μg/L milk lead (p < 0.0001, R2 = 0.3).

Conclusions: The M/P ratio for lead in humans is substantially higher than previously reported, and transfer of lead from plasma to milk may be higher at lower levels of plasma lead. Breast milk is an important determinant of lead burden among breastfeeding infants.
URL: https://ehp.niehs.nih.gov/1307187
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12689
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: 1Department of Chronic Disease Epidemiology, School of Public Health, Yale University, New Haven, Connecticut, USA; 2Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA; 3Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA; 4Department of Biology and Environmental Toxicology, University of California, Santa Cruz, Santa Cruz, California, USA; 5Division of Statistics, Center for Evaluation Research and Surveys, National Institute of Public Health, Cuernavaca, Morelos, México; 6Office of the Director, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; 7Office of the Director, National Institute of Public Health, Cuernavaca, Morelos, México

Recommended Citation:
Adrienne S. Ettinger,1,2 Ananya Roy,et al. Maternal Blood, Plasma, and Breast Milk Lead: Lactational Transfer and Contribution to Infant Exposure[J]. Environmental Health Perspectives,2014-01-01,Volume 122(Issue 1):87
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