globalchange  > 气候变化事实与影响
DOI: 10.1289/ehp.1206323
论文题名:
Domain-Specific Effects of Prenatal Exposure to PCBs, Mercury, and Lead on Infant Cognition: Results from the Environmental Contaminants and Child Development Study in Nunavik
作者: Olivier Boucher; 1; 2 Gina Muckle; 1; 3 Joseph L. Jacobson; 4 R. Colin Carter; 5 Melissa Kaplan-Estrin; 6 Pierre Ayotte; 1 Éric Dewailly; 1; S; ra W. Jacobson4
刊名: Environmental Health Perspectives
ISSN: 0091-7401
出版年: 2014
卷: Volume 122, 期:Issue 3
起始页码: 310
语种: 英语
英文摘要: Background: Polychlorinated biphenyls (PCBs), methylmercury (MeHg), and lead (Pb) are environmental contaminants known for their adverse effects on cognitive development.

Objectives: In this study we examined the effects of prenatal exposure to PCBs, MeHg, and Pb on cognitive development in a sample of Inuit infants from Arctic Québec.

Methods: Mothers were recruited at local prenatal clinics. PCBs, mercury (Hg), Pb, and two seafood nutrients—docosahexaenoic acid (DHA) and selenium (Se)—were measured in umbilical cord blood. Infants (n = 94) were assessed at 6.5 and 11 months of age on the Fagan Test of Infant Intelligence (FTII), A-not-B test, and Bayley Scales of Infant Development–2nd Edition (BSID-II).

Results: Multiple regression analyses revealed that higher prenatal PCB exposure was associated with decreased FTII novelty preference, indicating impaired visual recognition memory. Prenatal Hg was associated with poorer performance on A-not-B, which depends on working memory and is believed to be a precursor of executive function. Prenatal Pb was related to longer FTII fixation durations, indicating slower speed of information processing.

Conclusions: PCBs, MeHg, and Pb each showed specific and distinct patterns of adverse associations with the outcomes measured during infancy. By contrast, none of these exposures was associated with performance on the BSID-II, a global developmental measure. The more focused, narrow band measures of cognitive function that appeared to be sensitive to these exposures also provide early indications of long-term impairment in specific domains that would otherwise not likely be evident until school age.
URL: https://ehp.niehs.nih.gov/1206323
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12730
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: 1Centre de Recherche du Centre hospitalier universitaire de Québec, Québec City, Québec, Canada; 2Département de psychologie, Université de Montréal, Montréal, Québec, Canada; 3École de psychologie, Université Laval, Québec City, Québec, Canada; 4Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA; 5Department of Pediatrics, Division of Emergency Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA; 6Department of Psychology, Wayne State University, Detroit, Michigan, USA

Recommended Citation:
Olivier Boucher,1,2 Gina Muckle,et al. Domain-Specific Effects of Prenatal Exposure to PCBs, Mercury, and Lead on Infant Cognition: Results from the Environmental Contaminants and Child Development Study in Nunavik[J]. Environmental Health Perspectives,2014-01-01,Volume 122(Issue 3):310
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