globalchange  > 气候变化事实与影响
DOI: 10.1289/ehp.1307539
论文题名:
Standardizing Benchmark Dose Calculations to Improve Science-Based Decisions in Human Health Assessments
作者: Jessica A. Wignall; 1; rew J. Shapiro; 1 Fred A. Wright; 2 Tracey J. Woodruff; 3 Weihsueh A. Chiu; 4 Kathryn Z. Guyton; 4; Ivan Rusyn1
刊名: Environmental Health Perspectives
ISSN: 0091-7434
出版年: 2014
卷: Volume 122, 期:Issue 5
起始页码: 499
语种: 英语
英文摘要: Background: Benchmark dose (BMD) modeling computes the dose associated with a prespecified response level. While offering advantages over traditional points of departure (PODs), such as no-observed-adverse-effect-levels (NOAELs), BMD methods have lacked consistency and transparency in application, interpretation, and reporting in human health assessments of chemicals.

Objectives: We aimed to apply a standardized process for conducting BMD modeling to reduce inconsistencies in model fitting and selection.

Methods: We evaluated 880 dose–response data sets for 352 environmental chemicals with existing human health assessments. We calculated benchmark doses and their lower limits [10% extra risk, or change in the mean equal to 1 SD (BMD/L10/1SD)] for each chemical in a standardized way with prespecified criteria for model fit acceptance. We identified study design features associated with acceptable model fits.

Results: We derived values for 255 (72%) of the chemicals. Batch-calculated BMD/L10/1SD values were significantly and highly correlated (R2 of 0.95 and 0.83, respectively, n = 42) with PODs previously used in human health assessments, with values similar to reported NOAELs. Specifically, the median ratio of BMDs10/1SD:NOAELs was 1.96, and the median ratio of BMDLs10/1SD:NOAELs was 0.89. We also observed a significant trend of increasing model viability with increasing number of dose groups.

Conclusions: BMD/L10/1SD values can be calculated in a standardized way for use in health assessments on a large number of chemicals and critical effects. This facilitates the exploration of health effects across multiple studies of a given chemical or, when chemicals need to be compared, providing greater transparency and efficiency than current approaches.
URL: https://ehp.niehs.nih.gov/1307539
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12763
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: 1Department of Environmental Sciences and Engineering, and 2Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; 3Department of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of California, Oakland, California, USA; 4National Center for Environmental Assessment, U.S. Environmental Protection Agency, Washington, DC, USA

Recommended Citation:
Jessica A. Wignall,1,rew J. Shapiro,et al. Standardizing Benchmark Dose Calculations to Improve Science-Based Decisions in Human Health Assessments[J]. Environmental Health Perspectives,2014-01-01,Volume 122(Issue 5):499
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