globalchange  > 气候变化事实与影响
DOI: 10.1289/ehp.1306925
论文题名:
Association between Maternal Serum Perfluoroalkyl Substances during Pregnancy and Maternal and Cord Thyroid Hormones: Taiwan Maternal and Infant Cohort Study
作者: Yan Wang; 1 Walter J. Rogan; 1 Pau-Chung Chen; 2; 3; 4 Guang-Wen Lien; 2 Hsiao-Yen Chen; 5 Ying-Chih Tseng; 6 Matthew P. Longnecker; 1; Shu-Li Wang1; 5; 7
刊名: Environmental Health Perspectives
ISSN: 0091-7438
出版年: 2014
卷: Volume 122, 期:Issue 5
起始页码: 529
语种: 英语
英文摘要: Background: Perfluoroalkyl substances (PFASs) are synthetic compounds that are widely used in industry and are often detectable in humans. In pregnant rats and their pups, PFASs can interfere with thyroid hormone homeostasis. In humans, maternal thyroid hormones supply the fetus throughout pregnancy, and thyroid hormones play a critical role in fetal growth and neurodevelopment.

Objectives: We investigated the association between maternal PFAS exposure and thyroid hormone status in pregnant women and neonates.

Methods: In a study of environmental exposure and health in Taiwan, we measured serum concentrations of nine PFASs and four thyroid hormones for 285 pregnant women in their third trimester, and also measured cord serum thyroid hormones for 116 neonates. Associations between maternal PFASs and maternal and cord thyroid hormones were examined in multiple linear regression models.

Results: Perfluorohexanesulfonic acid concentrations were positively associated with maternal thyroid-stimulating hormone (TSH) levels. Pregnant women with higher levels of perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUnDA), and perfluorododecanoic acid (PFDoDA) had lower free thyroxine (T4) and total T4 levels. For example, we estimated that maternal free T4 levels decreased 0.019 ng/dL (95% CI: –0.028, –0.009) with each nanogram per milliliter increase in maternal PFNA. Finally, maternal PFNA, PFUnDA, and PFDoDA levels were associated with lower cord total triiodothyronine (T3) and total T4 levels, and maternal perfluorodecanoic acid (PFDeA) was associated with lower cord total T3.

Conclusions: Our results suggest that exposure to some PFASs during pregnancy may interfere with thyroid hormone homeostasis in pregnant women and fetuses.
URL: https://ehp.niehs.nih.gov/1306925
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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/12767
Appears in Collections:气候变化事实与影响
气候变化与战略

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作者单位: 1Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA; 2Institute of Occupational Medicine and Industrial Hygiene, and 3Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; 4Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan; 5Division of Environmental Health and Occupational Medicine, National Health Research Institutes, Miaoli, Taiwan; 6Department of Obstetrics and Gynecology, Hsinchu Cathay General Hospital, Hsinchu, Taiwan; 7Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan

Recommended Citation:
Yan Wang,1 Walter J. Rogan,1 Pau-Chung Chen,et al. Association between Maternal Serum Perfluoroalkyl Substances during Pregnancy and Maternal and Cord Thyroid Hormones: Taiwan Maternal and Infant Cohort Study[J]. Environmental Health Perspectives,2014-01-01,Volume 122(Issue 5):529
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