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A detailed understanding of species distribution is usually a prerequisite for the rehabilitation and utilization of species in an ecosystem. Paeonia veitchii (Paeoniaceae), which is an endemic species of China, is an ornamental and medicinal plant that features high economic and ecological values. With the decrease of its population in recent decades, it has become a locally endangered species. In present study, we modeled the potential distribution of P. veitchii under current and future conditions, and evaluated the importance of the factors that shape its distribution. The results revealed a highly and moderately suitable habitat for P. veitchii that encompassed ca. 605,114 km(2). The central area lies in northwest Sichuan Province. Elevation, temperature seasonality, annual mean precipitation, and precipitation seasonality were identified as the most important factors shaping the distribution of P. veitchii. Under the scenario with a low concentration of greenhouse gas emissions (RCP 2.6), we predicted an overall expansion of the potential distribution by 2050, followed by a slight contraction in 2070. However, with the scenario featuring intense greenhouse gas emissions (RCP 8.5), the range of suitable habitat should increase with the increasing intensity of global warming. The information that was obtained in the present study can provide background information related to the long-term conservation of this species.