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In the arid Hexi Corridor of northwest China, vegetation cover plays a pivotal role in sustaining the unique terrestrial ecosystem. In this paper, vegetation changes during growth season from April to October were investigated through examining the trends in the Normalized Difference Vegetation Index (NDVI) across the Hexi region. Based on the GMMIS NDVI 3g.v1 dataset, NDVI trend and its dependency on elevation and land cover were analyzed for the period 1982-2015 according to multiple statistical tests. Results showed that NDVI exhibited a significantly increasing trend in similar to 70% of the vegetated area, in contrast with a negative trend only in 2.85%. The resulting distinct groups with respect to decreasing, increasing and no trends presented significant differences in elevation and land cover composition, and the correlation between elevation, land cover and NDVI trend magnitude was subjected to precipitation and temperature change. The elevation and grassland cover were found to mainly account for variations in NDVI trend, and increase in elevation and various types of land cover excluding impervious and bare land would facilitate the trend magnitude. The dependency of NDVI trend on elevation and land cover was very vulnerable to increasing air temperature, which triggered an improvement in the vegetable activity to adapt to climate change, especially grass and forest. The contribution of crop and shrub to NDVI change was sensitive to precipitation trend change, but the crop was primarily influenced by human activities. The identified patterns of vegetation change would help to gain insights into the adapting mechanism of the fragile ecosystems in arid areas to changing environmental conditions.