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Alternate wetting and drying (AWD), has gained increasing attention as a promising strategy for mitigating greenhouse gas emissions (GHG) in flooded rice systems. AWD involves periodic drainage of rice paddies in order to inhibit methane (CH4) emissions. To date, studies evaluating this practice have been limited in their scope and resolution. Our study evaluates the mitigation potential of AWD from a life cycle perspective using highresolution CH4 modeling tomore accurately estimate themitigation potential of this practice. We simulated California rice production under continuous flooding and under five AWD schedules ranging in the severity and frequency of dry-downs. Production models were coupled with the Peatland Ecosystem Photosynthesis Respiration and Methane Transport (PEPRMT) model to simulate CH4 fluxes at daily intervals. We then evaluated the GHG mitigation potential of AWD using life cycle assessment models. Frequent or severe dry-downs reduced simulated grain yields, which negated some of the benefits of AWD when assessed on a yield-scaled basis. We also found AWD-induced mitigation of CH4 emissions modeled with PEPRMT to be roughly half the magnitude reported from up-scaling of chamber measurements, highlighting the importance of high resolution field data to better characterize GHGs in rice systems. Reduced yields and conservative CH4 mitigation in ourmodel lessened the overallmitigation potential of AWD. When the entire rice life cycle was considered, mitigation of overall global warming potential (GWP) was further reduced by the presence of additional GHGsources, which comprised roughly half of life cycle GWP. Our simulations resulted in <= 12% reductions inGWPkg-1 across all AWDscenarios and saw an increase in GWPwhen yields were severely reduced. Our results highlight the importance of constraining uncertainties in CH4 emissions and considering a life cycle perspective expressed on a yield-scaled basis in characterizing themitigation potential of AWD. (c) 2018 Elsevier B. V. All rights reserved.