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High-end climate change requires transformative solutions, as conventional strategies and solutions will not be enough if major disruptions in social-ecological systems are to be avoided. However, conventional climate assessment approaches and methods show many limitations if they are to provide robust knowledge and support to the implementation of such solutions in practice. To this end, we define transformative climate science as the open-ended process of producing, structuring, and applying solutions-oriented knowledge to fast-link integrated adaptation and mitigation strategies to sustainable development. In particular, based on our experiences within regional cases in Central Asia, Europe, Iberia, Scotland, and Hungary, we have selected 12 dimensions that scientists and practitioners can use as a checklist to design transformative-oriented climate assessments. While it is possible to talk both about transformative adaptation and transformative mitigation, in this paper, we make the case that societal transformation does not depend on mitigation or adaptation policies and actions, mostly because they are related to sustainability innovations, which are endogenous developments derived from deliberate social learning