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The objective of this study is to analyze the present and future climate-tourism conditions in Milos Island, Cyclades, Greece, by means of the assessment of the three climate components (physical, thermal, and aesthetic), which interprets the so-called climatic tourism potential. Milos Island is chosen as a representative island of the Cyclades complex in the Aegean Sea. Future climate change conditions are analyzed using the high-resolution simulations (grid size 0.11 degrees x 0.11 degrees) of the Regional Climate Model ALADIN 5.2 from Centre National de Recherche Meteorologiques, Meteo France (CNRM). The climate simulations concern the future periods 2021-2050 and 2071-2100 against the reference period 1961-1990, under two Representative Concentration Pathways, RCP4.5 and RCP8.5. Based on regional climate simulations, the tourism potential can be described in a meaningful and simple way by applying the Climate-Tourism-Information-Scheme (CTIS), which depicts detailed climate information that could be used by tourists to foresee the thermal comfort, aesthetic, and physical conditions for planning their vacations. More specifically, the thermal climate component is interpreted by the Physiologically Equivalent Temperature (PET), which is one of the most popular physiological thermal indices based on the human energy balance. The findings of the analysis could be used by stakeholders and the tourism industry in decision-making regarding the destination of Milos for tourism planning and touristic infrastructure development.