Amplified regional warming suggests that some regions suffer more from global warming. However, present knowledge is still not enough to understand this paramount aspect of global warming. By using climate model simulations, we first highlight that regional warming amplifications directly following anthropogenic emission would torment many undeveloped countries. Then, we find that cloud has the largest contribution to polar amplification, rather than the frequently blamed sea ice decline. The summertime sea ice decline plays the second role in generating strong wintertime polar amplification via lagged energy release. Our findings also propose that heat uptake by the deeper ocean greatly favors the terrestrial amplification. Additionally, the cloud also shows its importance in helping dryland amplification. Our findings suggest that these robust regional warming amplifications are very likely inevitable under anthropogenic emission, therefore strictest global mitigation is required to prevent unacceptable warming over the high risk regions.