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A residential building with cross-laminated timber structure in Granada (Spain) was analyzed using the life cycle assessment methodology, life cycle energy analysis and sensitivity analysis to changes in efficiency of operating energy, materials database, transport distances and different scenarios for C&DW. The environmental impacts of the materials and construction production and embedded energy were relatively significant. The global warming impact category was very low due to the CO2 sequestration of wooden materials. Sensitivity analysis revealed that the most significant reduction in environmental impact was achieved through improvements in energy efficiency, high uncertainty in the impacts of the environmental product declaration, the low effect of long-distance transport on the overall impact and the feasibility of the objective of recovery of the Waste Framework Directive by 2020 (above 70%).