globalchange  > 气候变化事实与影响
DOI: 10.1016/j.neuroscience.2019.01.023
WOS记录号: WOS:000462917500033
论文题名:
Towards Establishing Age-Related Cortical Plasticity on the Basis of Somatosensation
作者: Hanley, Claire J.1; Burianova, Hana1,2; Tommerdahl, Mark3
通讯作者: Hanley, Claire J.
刊名: NEUROSCIENCE
ISSN: 0306-4522
EISSN: 1873-7544
出版年: 2019
卷: 404, 页码:407-412
语种: 英语
英文关键词: ageing ; neural plasticity ; somatosensory ; vibrotactile adaptation
WOS关键词: VIBRATORY ADAPTATION ; ALZHEIMERS-DISEASE ; COGNITIVE DECLINE ; WHITE-MATTER ; MECHANISMS ; DYNAMICS ; MAGNITUDE ; CAPACITY
WOS学科分类: Neurosciences
WOS研究方向: Neurosciences & Neurology
英文摘要:

Age-related somatosensory processing appears to remain intact where tasks engage centrally- as opposed to peripherally-mediated mechanisms. This distinction suggests that insight into alterations in neural plasticity could be derived via metrics of vibrotactile performance. Such an approach could be used to support the early detection of global changes in brain health but current evidence is limited. Knowledge of the precise conditions in which older adults are expected to sustain somatosensory performance is largely unknown. For this purpose, the study aimed to characterize age-related performance on tactile detection and discrimination-based tests. Accordingly, a group of young and older adult participants took part in simple reaction time and amplitude discrimination tasks. Participants' ability to distinguish between stimuli on the basis of amplitude was assessed with and without dual-site adaptation, which has been proposed to refine cortical responses and improve behavioral performance. The results show that while older adults exhibited significantly prolonged (p < .001, d = 1.116) and more variable (p = .022, d = 0.578) information processing speed compared to young adults, they were able to achieve similar scores in baseline discrimination (p = .179, d = 0.336). We also report, for the first time, that older adults displayed similar performance improvements to young adults, under conditions of dual-site adaptation (p = .948, d = 0.016). The findings support the argument that centrally-mediated mechanisms remain intact in the ageing population. Accordingly, dual-site adaptation data provide compelling new evidence of somatosensation in ageing that will contribute towards the development of an assessment tool to ascertain pre-clinical, age-related changes in the status of cortical function. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved.


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资源类型: 期刊论文
标识符: http://119.78.100.158/handle/2HF3EXSE/134312
Appears in Collections:气候变化事实与影响

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作者单位: 1.Swansea Univ, Dept Psychol, Swansea, W Glam, Wales
2.Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia
3.Univ N Carolina, Dept Biomed Engn, Chapel Hill, NC 27515 USA

Recommended Citation:
Hanley, Claire J.,Burianova, Hana,Tommerdahl, Mark. Towards Establishing Age-Related Cortical Plasticity on the Basis of Somatosensation[J]. NEUROSCIENCE,2019-01-01,404:407-412
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