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In this study, an empirical assessment approach for the risk of crop loss due to water stress was developed and used to evaluate the risk of winter wheat loss in China, the United States, Germany, France and the United Kingdom. We combined statistical and remote sensing data on crop yields with climate data and cropland distribution to model the effect of water stress from 1982 to 2011. The average value of winter wheat loss due to water stress for the three European countries was about -931 kg/ha, which was higher than that in China (-570 kg/ha) and the United States (-367 kg/ha). Our study has important implications for the operational assessment of crop loss risk at a country or regional scale. Future studies should focus on using higher spatial resolution remote sensing data, combining actual evapotranspiration to estimate water stress, improving the method for downscaling of statistical crop yield data and establishing more sophisticated zoning methods.