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Each glacial - interglacial transition of the Quaternary occurs in a different orbital context leading to various timing for the deglaciation and sequence of high vs low latitudes events. Termination 3, 250 kyears before present (ka), is an unusual deglaciation in the context of the last 9 deglaciations recorded in the old EPICA Dome C (EDC) Antarctic ice core: it exhibits a three-phase sequence, two warming phases separated by a small cooling, the last phase suggesting a particularly rapid temperature increase. We present here new high resolution delta N-15 and deuterium excess (d-excess) data from the EDC ice core to provide a detailed temperature change estimate during this termination. Then, we combined the delta D and delta O-18 to discuss the relationship between high and low latitude changes through the d-excess. We also provide the high vs low latitude sequence of events over this deglaciation without chronological uncertainty using low latitude ice core proxies. In agreement with previous studies based on speleothem analyses, we show that the first phase of Termination 3 (256-249 ka) is associated with small Heinrich like events linked to changes in ITCZ position, monsoon activity and teleconnections with Antarctica. In a context of minimum Northern Hemisphere insolation, this leads to a rather strong Antarctic warming, as observed in the delta N-15 record in contrast to the relatively small delta D increase. The second warming phase occurs during the rise of the Northern hemisphere insolation, with a large Heinrich like event leading to the characteristic Antarctic warming observed in the delta N-15 and delta D increase as for the more recent terminations. (C) 2019 Elsevier Ltd. All rights reserved.